Synthesis of Albumin/DCP Nano-Composite Particles

Ohsawa, Hajime; Ito, Atsuo; Sogo, Yu; Yamazaki, Atsushi; Ohno, Tadao

doi:10.4028/0-87849-422-7.239

Cited by 2 publications

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“…Selected examples and typical applications of each category of nanodimensional materials and their use in biomedical applications are available in literature [116]. It is important to note, that in literature on calcium orthophosphates there are cases, when the prefix "nano" has been applied for the structures, with the minimum dimensions exceeding 100 nm[44, 83,[117][118][119][120][121][122][123][124][125][126][127][128][129][130][131][132][133].…”

Section: General Information On "Nano"mentioning

confidence: 99%

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Dorozhkin¹

2012

AJBE

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Nano-sized particles and crystals play an important role in the formation of calcified tissues of various animals. For example, nano-sized and nanocrystalline calcium orthophosphates in the form of apatites of biological origin represent the basic inorganic building blocks of bones and teeth of mammals. Namely, according the recent developments in biomineralization, tens to hundreds nanodimensional crystals of a biological apatite are self-assembled into these complex structures. This process occurs under a strict control by bioorganic matrixes. Furthermore, both a greater viability and a better proliferation of various types of cells have been detected on smaller crystals of calcium orthophosphates. Thus, the nano-sized and nanocrystalline forms of calcium orthophosphates have a great potential to revolutionize the hard tissue-engineering field, starting from bone repair and augmentation to controlled drug delivery systems. This review reports on current state of the art and recent developments on the subject, starting from synthesis and characterization to biomedical and clinical applications. Furthermore, the review also discusses possible directions for future research and development.

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Section: General Information On "Nano"mentioning

confidence: 99%

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Dorozhkin¹

2012

AJBE

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“…Selected examples and typical applications of each category of nanomaterials and their use in biomedical applications are available in literature [116]. It is important to note, that in literature on calcium orthophosphates there are cases, when the prefix “nano” has been applied for the structures, with the minimum dimensions exceeding 100 nm [42,70,117,118,119,120,121,122,123]. …”

Section: General Information On “Nano”mentioning

confidence: 99%

“…However, there is a study in which an increase of particle and crystallite sizes of TCP did not prolong but shortened the induction time until the cement setting reaction started [422], which was against the common physical rules (generally, smaller particles or crystallites should enhance reactivity). Nevertheless, two general directions of the biomedical application of nanodimensional and nanocrystalline calcium orthophosphates can be outlined: (i) using them in powder form as filling materials to impart bioactivity to various biocomposites and hybrid biomaterials [52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,167,478]; (ii) manufacturing of either dense compacts or porous scaffolds, possessing the sufficient mechanical properties [62,79,264,265,464,465,479,480]. As the nanodimensional and nanocrystalline calcium orthophosphates tend to agglomerate at heating (Figure 6) [277,481,482,483], normally a low-temperature [157,297] and/or a rapid consolidation [157,…”

Section: Biomedical Applications Of the Nanodimensional And Nanocrmentioning

confidence: 99%

“…To narrow the subject of the review, with a few important exceptions, undoped and un-substituted calcium orthophosphates are considered and discussed only. The readers interested in various nanodimensional and nanocrystalline ion-substituted calcium orthophosphates [25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51], calcium orthophosphate-based nanocomposites [52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70] or nanodimensional calcium orthophosphate-based composites [71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86] are advised to read the original papers. Furthermore, addi...…”

Section: Introductionmentioning

confidence: 99%

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Nanodimensional and Nanocrystalline Apatites and Other Calcium Orthophosphates in Biomedical Engineering, Biology and Medicine

Dorozhkin¹

2009

Materials

243

150

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Recent developments in biomineralization have already demonstrated that nanosized particles play an important role in the formation of hard tissues of animals. Namely, the basic inorganic building blocks of bones and teeth of mammals are nanodimensional and nanocrystalline calcium orthophosphates (in the form of apatites) of a biological origin. In mammals, tens to hundreds nanocrystals of a biological apatite were found to be combined into self-assembled structures under the control of various bioorganic matrixes. In addition, the structures of both dental enamel and bones could be mimicked by an oriented aggregation of nanosized calcium orthophosphates, determined by the biomolecules. The application and prospective use of nanodimensional and nanocrystalline calcium orthophosphates for a clinical repair of damaged bones and teeth are also known. For example, a greater viability and a better proliferation of various types of cells were detected on smaller crystals of calcium orthophosphates. Thus, the nanodimensional and nanocrystalline forms of calcium orthophosphates have a great potential to revolutionize the field of hard tissue engineering starting from bone repair and augmentation to the controlled drug delivery devices. This paper reviews current state of knowledge and recent developments of this subject starting from the synthesis and characterization to biomedical and clinical applications. More to the point, this review provides possible directions of future research and development.

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Synthesis of Albumin/DCP Nano-Composite Particles

Cited by 2 publications

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Nanodimensional and Nanocrystalline Calcium Orthophosphates

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Nanodimensional and Nanocrystalline Apatites and Other Calcium Orthophosphates in Biomedical Engineering, Biology and Medicine

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