Synthesis of adamantane and bicyclo[3.3.1]nonane derivatives with the oxetane moiety

Design, synthesis and bioactivity of simplified taxol analogues on the basis of bicyclo[3.3.1]nonane derivatives

“…To obtain compound 5, double esterification was performed for TMS protected 7-endo-hydroxybicyclo[3.3.1]nonane carboxylic acid 14, first by 3-hydroxyoxetane (obtained in five steps from glycerol) 20 and then by a protected amino acid (Scheme 4).…”