The review describes the syntheses and probable biologically active conformations of taxol, a natural antitumor agent, and systematizes published data on the structure-activity relations in the series of taxol analogs.
Structure-activity relationships for ligands of the colchicine site of tubulin were analyzed based on their common pharmacophore. The role of the elucidation of the three dimensional structure of the colchicine site of tubulin on the development of studies aimed at the search for the ligands of this site is analyzed.
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