Synthesis of a smart Janus-like supramolecular polymer based on the host–guest chemistry and its self-assembly

Yang, Long; Guo, Yinzhou; Lei, Zhongli

doi:10.1039/c5ta03937a

Cited by 12 publications

(8 citation statements)

References 28 publications

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“…SDDBCs can be produced by adding a uniform or distinct dendritic block as “tree root” to the structure of SLDBCs via non‐covalent interactions such as metal–ligand coordination . SDDBCs with different amount of dendritic terminal units can be considered as Janus polymers, which have attracted great attention due to their unique asymmetric structures and functionalization, showing great potential to be new building blocks in self‐assembly . Many unique phenomena were observed, such as self‐assembly, rotation, and self‐propulsion attributed to the asymmetric Janus structures .…”

Section: Structures Properties and Functions Of Nonlinear Supramolementioning

confidence: 99%

Nonlinear Supramolecular Polymers for Therapeutic Applications

Chen

Kretzschmann

Tian

et al. 2018

Advanced Therapeutics

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An elegant combination of supramolecular polymers exhibiting nonlinear topological structures results in a series of brand new, nonlinear supramolecular polymers. Recently, these polymers have attracted increased attention in various fields due to their diverse and advantageous properties. Especially in therapeutic applications, one can take advantage of their unique chemical, physical, and biological properties such as degradability and stimuli‐responsiveness. Due to the large number of possible module modifications, such polymers have great potential as platforms in disease treatments. In this review, the structures, properties, and functions of different nonlinear supramolecular polymers are summarized. Current therapeutic applications are presented and the prospective design trends are discussed for promoting the development of nonlinear supramolecular polymers.

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Section: Structures Properties and Functions Of Nonlinear Supramolementioning

confidence: 99%

Nonlinear Supramolecular Polymers for Therapeutic Applications

Chen

Kretzschmann

Tian

et al. 2018

Advanced Therapeutics

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“…Compared with PPEGMA‐PDMAEMA‐PNIPAM‐P t BMA, the characteristic peak of tertiary butyl at 1.41 ppm of the tetrablock copolymer PPEGMA‐PDMAEMA‐PNIPAM‐PMAA had almost disappeared, and a new peak was found at 12.33 ppm, as shown in Figure . Figure S9(e) shows that the special vibration peaks of tertiary butyl groups at 1392 and 1369 cm −1 became very weak, signifying that the esterolysis reaction of tertiary butyl and the synthesis of PPEGMA‐PDMAEMA‐PNIPAM‐PMAA were achieved …”

Section: Resultsmentioning

confidence: 99%

“…Poly(ethylene glycol) methyl ether methacrylate (PEGMA, M n = 300 Da, Sigma‐Aldrich, 99%) was passed through a neutral alumina column to remove the inhibitor. Tris[2‐(dimethylamino)ethyl]amine (Me 6 ‐TREN) was prepared according to our previous work . Dichloromethane (DCM), isopropanol (IPA), and N,N ‐dimethylformamide (DMF) were distilled from calcium hydride.…”

Section: Methodsmentioning

confidence: 99%

“…Stimuli‐responsive polymeric micelles (SRPM) can undergo reversible or irreversible changes in internal structure or charge, even an aggregation state, in response to exogenous or endogenous stimuli (light, temperature, pH, sugar, and redox agents) . Therefore, the SRPM systems have garnered gigantic attention and development as ideal drug carriers.…”

Section: Introductionmentioning

confidence: 99%

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Temperature, pH, and reduction triple‐stimuli‐responsive inner‐layer crosslinked micelles as nanocarriers for controlled release

Zhang

Liu

et al. 2018

J of Applied Polymer Sci

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Temperature, pH, and reduction triple‐stimuli‐responsive inner‐layer crosslinked micelles as nanocarriers for drug delivery and release are designed. The well‐defined tetrablock copolymer poly(polyethylene glycol methacrylate)–poly[2‐(dimethylamino) ethyl methacrylate]–poly(N‐isopropylacrylamide)–poly(methylacrylic acid) (PPEGMA‐PDMAEMA‐PNIPAM‐PMAA) is synthesized via atom transfer radical polymerization, click chemistry, and esterolysis reaction. The tetrablock copolymer self‐assembles into noncrosslinked micelles in acidic aqueous solution. The core‐crosslinked micelles, shell‐crosslinked micelles, and shell–core dilayer‐crosslinked micelles are prepared via quaternization reaction or carbodiimide chemistry reaction. The crosslinked micelles are used as drug carriers to load doxorubicin (DOX), and the drug encapsulation efficiency with 20% feed ratio reached 59.2%, 73.1%, and 86.1%, respectively. The cumulative release rate of DOX is accelerated by single or combined stimulations. The MTT (3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide) assay verifies that the inner‐layer crosslinked micelles show excellent cytocompatibility, and DOX‐loaded micelles exhibit significantly higher inhibition for HepG2 cell proliferation. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46714.

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“…When polymeric micelles were designed to release anticancer drugs, they were expected to possess not only good blood stability but also stimulus‐responsive properties. Therefore, numerous types of stimuli‐responsive polymeric micelles have been utilized for drug delivery, including reduction‐, pH‐, light‐, and temperature‐responsive polymeric micelles . Redox‐stimuli‐responsive polymeric micelles have emerged as a good candidate for anticancer drug treatment, especially as disulfide bonds were introduced into the polymeric micelles .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of light and dual‐redox triple‐stimuli‐responsive core‐crosslinked micelles as nanocarriers for controlled release

Liu

Lei

et al. 2019

J of Applied Polymer Sci

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Stimulus-responsive polymeric nanoparticles have great potential as nanocarriers. Here, triple-stimuli-responsive corecrosslinked (CCL) micelles were developed that were convenient for drug delivery by taking advantage of dual-redox and UV light synergistic triggers. Amphiphilic block copolymers methoxy poly(ethylene glycol)-b-poly(3-azido-2-hydroxy-propyl methacrylate-co-οnitrobenzyl methacrylate) [mPEG-b-P(GMA-N 3 -co-NBM)] were synthesized via atom transfer radical polymerization and ring-opening reaction of ethylene oxide; these block copolymers can spontaneously self-assemble into noncrosslinked (NCL) micelles. Afterward, CCL micelles were prepared using an alkyne-functionalized crosslinking agent. Furthermore, the CCL micelles showed an excellent Nile Red dye molecule encapsulation, light and dual-redox-responsive performance, and increasing release rate of the dye as the concentration of glutathione and light irradiation increased. The triple-stimuli-responsive CCL micelles showed excellent stability and controllable release compared to NCL micelles. Therefore, we have developed a new smart nanocarrier, and the triple-stimuli-responsive CCL micelles could also be a potential delivery system in cancer therapy.

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Synthesis of a smart Janus-like supramolecular polymer based on the host–guest chemistry and its self-assembly

Cited by 12 publications

References 28 publications

Nonlinear Supramolecular Polymers for Therapeutic Applications

Nonlinear Supramolecular Polymers for Therapeutic Applications

Temperature, pH, and reduction triple‐stimuli‐responsive inner‐layer crosslinked micelles as nanocarriers for controlled release

Synthesis of light and dual‐redox triple‐stimuli‐responsive core‐crosslinked micelles as nanocarriers for controlled release

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