Synthesis of a Novel Glycopeptide by Polymeranalogous Reaction of Gelatin with Mono‐6‐<i>para</i>‐toluenesulfonyl‐β‐cyclodextrin and its Supramolecular Properties

Bernert, Dominika B.; Isenbügel, Kathrin; Ritter, Helmut

doi:10.1002/marc.201000554

Cited by 10 publications

(9 citation statements)

References 22 publications

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“…1d, and e, Video 1), indicating the robustness of the inter-gelatin host-guest crosslinking. In contrast, it has been reported that the b-CD-grafted gelatin can only form a viscous solution rather than stable hydrogels above 30 C [39]. Such ineffective hydrogel formation are likely attributed to the inefficient host-gust interaction due to the unfavorable entropy of binding between the aromatic residuals and b-CD when they are both fixed on the bulky polymer backbones [46].…”

Section: Fabrication Of Supramolecular Hgm Hydrogelsmentioning

confidence: 82%

Mechanically resilient, injectable, and bioadhesive supramolecular gelatin hydrogels crosslinked by weak host-guest interactions assist cell infiltration and in situ tissue regeneration

et al. 2016

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Section: Fabrication Of Supramolecular Hgm Hydrogelsmentioning

confidence: 82%

Mechanically resilient, injectable, and bioadhesive supramolecular gelatin hydrogels crosslinked by weak host-guest interactions assist cell infiltration and in situ tissue regeneration

et al. 2016

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“…1 H-NMR (500 Hz, D 2 O) was conducted to verify whether the pluronic was successfully grafted to the gelatin backbone. As shown in Figure 2 and compared with another study [46,47,48], 1 H-NMR spectrum of GP-F127 includes both proton signals of the amino acid-forming gelatin and proton signals of F127. The peaks at 0.87 ppm is assigned to the methyl protons resonance of Leucine (Leu), Valine (Val) and Isoleucine (Ile).…”

Section: Resultsmentioning

confidence: 79%

Dual Interactions of Amphiphilic Gelatin Copolymer and Nanocurcumin Improving the Delivery Efficiency of the Nanogels

et al. 2019

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Herein, a new process to manufacture multicore micelles nanoparticles reinforced with co-assembly via hydrophobic interaction and electrostatic interaction under the help of ultrasonication was developed. The precise co-assembly between negative/hydrophobic drug and positive charged amphiphilic copolymer based pluronic platform allows the formation of complex micelles structures as the multicore motif with predefined functions. In this study, curcumin was selected as a drug model while positively charged copolymer was based on a pluronic-conjugated gelatin with different hydrophobicity length of Pluronic F87 and Pluronic F127. Under impact of dual hydrophobic and electrostatic interactions, the nCur-encapsulated core–shell micelles formed ranging from 40 nm to 70 nm and 40–100 nm by transmission electron microscopy (TEM) and Dynamic Light Scattering (DLS), respectively. It is found that the structures emerged depended on the relative lengths of the hydrophobic blocks in pluronic. Regarding g2(τ) behavior from DLS measurement, the nanogels showed a high stability in spherical form. Surprisingly, the release profiles showed a sustainable behavior of Cur from this system for drug delivery approaches. In vitro study exhibited that nCur-encapsulated complex micelles increased inhibitory activity against cancer cells growth with IC50 is 4.02 ± 0.11 mg/L (10.92 ± 0.3 µM) which is higher than of free curcumin at 9.40 ± 0.17 mg/L (25.54 ± 0.18 µM). The results obtained can provide the new method to generate the hierarchical assembly of copolymers with incorporated loading with the same property.

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“…The peaks at 2.65, 2.94, 3.16, and 3.58 ppm were derived from the amino acids aspartic acid (Asp), lysine (Lys), Arg, and proline (Pro). The resonance of the aromatic protons of tyrosine (Phe) appeared at 7.28 ppm ( Figures 1A,C ) ( Bernert et al, 2011 ). From the NMR spectrum ( Figure 1B ), we can see that the 1H of glucose derived from CD was apparent at 4.97 ppm.…”

Section: Resultsmentioning

confidence: 99%

The Influence of Shuttle-Shape Emodin Nanoparticles on the Streptococcus suis Biofilm

et al. 2018

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Biofilm is one of the most important physiological protective barriers of the Streptococcus suis (S. suis), and it is also one of the primary causes of hindrance to drug infiltration, reduction of bactericidal effects, and the development of antibiotic resistance. In order to intervene or eliminate S. suis biofilm, shuttle-shape emodin-loaded nanoparticles were developed in our study. The emodin nanoparticles were prepared by emodin and gelatin–cyclodextrin which was synthesized as drug carrier, and the nanoparticles were 174 nm in size, -4.64 mv in zeta potential, and exhibited a sustained emodin release. Moreover, the delivery kinetics of nanoparticles were also explored in our study. The confocal laser scanning microscopy and colony forming unit enumeration experiment indicated that nanoparticles could increase drug infiltration and uptake by biofilm. The flow cytometry system analysis showed that nanoparticles could be up taken by 99% of the bacteria cells. TCP assay and scanning electron microscopy showed that the nanoparticles had better effect on biofilm inhibition and elimination when compared with emodin solution. These results revealed that the emodin nanoparticles had a better therapeutic effect on the S. suis biofilm in vitro.

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Synthesis of a Novel Glycopeptide by Polymeranalogous Reaction of Gelatin with Mono‐6‐para‐toluenesulfonyl‐β‐cyclodextrin and its Supramolecular Properties

Cited by 10 publications

References 22 publications

Mechanically resilient, injectable, and bioadhesive supramolecular gelatin hydrogels crosslinked by weak host-guest interactions assist cell infiltration and in situ tissue regeneration

Mechanically resilient, injectable, and bioadhesive supramolecular gelatin hydrogels crosslinked by weak host-guest interactions assist cell infiltration and in situ tissue regeneration

Dual Interactions of Amphiphilic Gelatin Copolymer and Nanocurcumin Improving the Delivery Efficiency of the Nanogels

The Influence of Shuttle-Shape Emodin Nanoparticles on the Streptococcus suis Biofilm

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