Synthesis of a novel chiral DA-TD covalent organic framework for open-tubular capillary electrochromatography enantioseparation

Abstract

Herein, a novel chiral covalent organic framework, DA-TD COF, with good chemical/thermal stability was synthesized and used as chiral stationary phase for open-tubular capillary electrochromatography enantioseparation. The DA-TD COF coated...

Recent Advances in Separation and Analysis of Chiral Compounds

“…A novel chiral COF CB-DA COF, consisting of (S)-1,3,5-tri­(4-aminophenyl)-2-(2-methylbutoxy)­benzene (CB) and 2,5-dimethoxyterephthalaldehyde (DA), was covalently bound on amino or epoxy group functionalized silica capillary. The prepared CB-DA-COF-based capillary exhibited great enantio-resolution of chiral drugs including terbutaline, propranolol, phenylephrine, verapamil, norepinephrine, and isoprenaline. , Diphenylmethane diisocyanate-β-CD (MDI-β-CD) modified 1,3,5-triformylphloroglucinol was condensed with p-phenylenediamine to produce a chiral COF of MDI-β-CD-COF. The excellent chiral recognition of MDI-β-CD in conjunction with the unique structure of COF provided MDI-β-CD-COF superior enantioselectivity for atenolol and amlodipine besylate.…”

Challenges and opportunities for chiral covalent organic frameworks

“…As such, it is reasonable to envision that CCOFs can only be correctly modelled in Sohncke space groups while meeting reticular chemistry requirements. To date, there are three wellestablished synthetic strategies to construct CCOFs: (1) Direct synthesis: using optically pure monomers as cross-linking building units to directly synthesise CCOFs; [19][20][21][22][23][24][25] (2) Post-synthetic modification (PSM): reacting achiral parent COFs with chiral molecules to engender chirality via the post-synthetic modifications; [26][27][28][29] (3) Chiral induction synthesis: using chiral inducing agents to synthesise CCOFs solely from achiral components. [30][31][32] This section will review these three synthetic methods for CCOFs.…”

Enhanced Chiral Recognition Abilities of Cyclodextrin Covalent Organic Frameworks via Chiral/Achiral Functional Modification

“…In order to improve the diversity and efficiency of separation, porous materials have been developed as the CSP due to their intriguing structural merits, such as the tunable pore size, large specific surface area, and flexible modification . To date, various emerging materials including carbon nanomaterials, , mesoporous silica, − metal organic frameworks, − and covalent organic frameworks (COFs) , have been used to construct the CSP for enantioseparation.…”