Synthesis of a new oxazoline macromonomer for dispersion polymerization

Jerca, Valentin Victor; Nicolescu, Florica Adriana; Vasilescu, Dan Sorin; Vuluga, Dumitru Mircea

doi:10.1007/s00289-010-0312-z

Cited by 21 publications

(10 citation statements)

References 17 publications

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“…Semitelechelic pMeOx was subsequently used as macroinitiator for the RAFT polymerization of styrene. Vuluga et al used methylvinyldichlorosilane as bifunctional initiator for the CROP of EtOx, yielding pEtOx bearing a center-vinyl group [88]. This macromer was used in free-radical dispersion copolymerizations with styrene, yielding monodisperse microspheres.…”

Section: Combination Of Crop and Controlled-radical Polymerizationsmentioning

confidence: 99%

Design Strategies for Functionalized Poly(2-oxazoline)s and Derived Materials

2013

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Abstract:The polymer class of poly(2-oxazoline)s currently is under intensive investigation due to the versatile properties that can be tailor-made by the variation and manipulation of the functional groups they bear. In particular their utilization in the biomedic(in)al field is the subject of numerous studies. Given the mechanism of the cationic ring-opening polymerization, a plethora of synthetic strategies exists for the preparation of poly(2-oxazoline)s with dedicated functionality patterns, comprising among others the functionalization by telechelic end-groups, the incorporation of substituted monomers into (co)poly(2-oxazoline)s, and polymeranalogous reactions. This review summarizes the current state-of-the-art of poly(2-oxazoline) preparation and showcases prominent examples of poly(2-oxazoline)-based materials, which are retraced to the desktop-planned synthetic strategy and the variability of their properties for dedicated applications.

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Section: Combination Of Crop and Controlled-radical Polymerizationsmentioning

confidence: 99%

Design Strategies for Functionalized Poly(2-oxazoline)s and Derived Materials

2013

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“…Those studies demonstrated that lower amounts of macromonomers are required compared to conventional stabilizers to obtain microspheres with controlled diameter and narrow polydispersity . Our group has previously reported on the synthesis and stabilizing properties of gemini type PAOx macromonomers . Compared to other conventional macromonomers, these are known to exhibit a superior dispersing performance .…”

Section: Introductionmentioning

confidence: 99%

Factorial design optimization of polystyrene microspheres obtained by aqueous dispersion polymerization in the presence of poly(2‐ethyl‐2‐oxazoline) reactive stabilizer

Iordache

Banu

Giol

et al. 2020

Polymer International

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The present study highlights the use of statistical design to establish an effective model for the synthesis of polystyrene microspheres by aqueous dispersion polymerization using poly(2-ethyl-2-oxazoline) reactive stabilizer. The significant parameters (e.g. solvent polarity, stabilizer and initiator concentration) influencing the characteristic responses of the process such as yield, particle size and size distribution, as well as the interactions between the variables, were identified. The macromonomer concentration and solvent polarity influence both particle size and size distribution, whereas initiator concentration influences the yield. Analysis of the variance of process variables indicates that the models can be successfully used to describe the dispersion polymerization process. Moreover, the factorial design allows the development of microspheres with optimal properties with respect to size and size distribution. The experimental data regarding yield, particle size and size distribution of the optimized dispersion polymerization shows less than 7% difference compared with the predicted responses. In view of these results, the implementation of statistical design models represents an efficient solution for optimizing microparticle synthesis while aiming for industrial applications.

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“…37,46 They can be regarded as interesting new hydrogels for biomedical applications, as PAOx exhibit good biocompatibility, hydrophilicity, and enable orthogonal functionalization possibilities, which has been well documented in recent years. 18,35,37,[47][48][49][50][51][52] Nevertheless, up to date there is no polymer that fulfills all the requirements for an ideal hydrogel with respect to its chemical nature, biocompatibility and biodegradability, and the chemical bond forming events to create covalent cross-links. Consequently, finding and investigating other alternative polymers represent the focus of the ongoing research.…”

Section: Introductionmentioning

confidence: 99%

Poly(2-isopropenyl-2-oxazoline) Hydrogels for Biomedical Applications

et al. 2018

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Synthetic polymers have had a major impact on the biomedical field. However, all polymers have their advantages and disadvantages, so that the selection of a certain polymeric material always is a compromise with regard to many properties, such as synthetic accessibility, solubility, thermal properties, biocompatibility and degradability. The development of novel polymers with superior properties for medical applications is the focus of many research groups. The present study highlights the use of poly(2-isopropenyl-2-oxazoline) (PiPOx), as biocompatible functional polymer to develop synthetic hydrogel materials using a simple straightforward synthesis protocol. A library of hydrogels was obtained by chemical cross-linking of PiPOx, using eight different non-toxic and bio-based dicarboxylic acids. The equilibrium swelling degree (ESD) of the final material can be modulated by simple modification of the composition of the reaction mixture, including the polymer concentration in the feed ratio between the 2-oxazoline pendent groups and the carboxylic acid groups as well as the cross-linker 2 length. The hydrogels with the highest water uptake were selected for further investigations regarding their potential use as biomaterials. We evaluated the thermoresponsiveness, the pH-degradability under physiological conditions and demonstrated proof-of-concept drug delivery experiments. The in vitro cellular studies demonstrated the noncytotoxic character of the PiPOx hydrogels, and its protein repellent properties, while mineralization studies revealed that such scaffolds do not promote mineralization/calcification phenomena. In view, of these results, these hydrogels show potential use as ophthalmologic materials or in drug delivery applications.

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Synthesis of a new oxazoline macromonomer for dispersion polymerization

Cited by 21 publications

References 17 publications

Design Strategies for Functionalized Poly(2-oxazoline)s and Derived Materials

Design Strategies for Functionalized Poly(2-oxazoline)s and Derived Materials

Factorial design optimization of polystyrene microspheres obtained by aqueous dispersion polymerization in the presence of poly(2‐ethyl‐2‐oxazoline) reactive stabilizer

Poly(2-isopropenyl-2-oxazoline) Hydrogels for Biomedical Applications

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