Synthesis of a covalent organic framework with hydrazine linkages and its application in open-tubular capillary electrochromatography

Wang, Fangling; Zhang, Yanli; Wang, Guoxiu; Qi, Shengda; Lv, Wenjuan; Liu, Juanjuan; Chen, Hongli; Chen, Xingguo

doi:10.1016/j.chroma.2021.462681

Cited by 22 publications

(13 citation statements)

References 38 publications

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“…Capillary electrochromatography (CEC) was utilized to explore whether the reaction of L-TCDs and H 2 O 2 generated a new substance. 56 Figure 6A shows that a new peak appeared at 4.3 min after the addition of H 2 O 2 , and the intensity of the second peak after 6 min decreased significantly, which proves that new substances were indeed generated after being etched by H 2 O 2 . The new peak that appeared at 4.3 min is apparent after adding D-Gln, while the phenomenon is entirely different upon adding L-Gln.…”

Section: ■ Results and Discussionmentioning

confidence: 78%

“…We contemplate that the dual-mode response signals might stem from the etching products of L-TCDs. Capillary electrochromatography (CEC) was utilized to explore whether the reaction of L-TCDs and H 2 O 2 generated a new substance Figure A shows that a new peak appeared at 4.3 min after the addition of H 2 O 2 , and the intensity of the second peak after 6 min decreased significantly, which proves that new substances were indeed generated after being etched by H 2 O 2 .…”

Section: Resultsmentioning

confidence: 99%

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Fluorescent/Colorimetric Dual-Mode Discriminating Gln and Val Enantiomers Based on Carbon Dots

Liao,

Wu,

et al. 2023

Anal. Chem.

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Discrimination and quantification of amino acid (AA) enantiomers are particularly important for diagnosing and treating diseases. Recently, dual-mode probes have gained a lot of research interest because they can catch more detecting information compared with the single-mode probes. Thus, it is of great significance to develop a dual-mode sensor realizing AA enantiomer discrimination conveniently and efficiently. In this work, carbon dot L-TCDs were prepared by N-methyl-1,2benzenediamine dihydrochloride (OTD) and L-tryptophan. With the assistance of H 2 O 2 , L-TCDs show an excellent discrimination performance for enantiomers of glutamine (Gln) and valine (Val) in both fluorescent and colorimetric modes. The fluorescence enantioselectivity of Gln (F D /F L ) and Val (F L /F D ) is 5.29 and 4.13, respectively, and the colorimetric enantioselectivity of Gln (I D /I L ) and Val (I L /I D ) is 13.26 and 3.42, individually. The chiral recognition mechanism of L-TCDs was systematically studied. L-TCDs can be etched by H 2 O 2 , and the participation of AA enantiomers results in different amounts of the released OTD, which provides fluorescent and colorimetric signals for identifying and quantifying the enantiomers of Gln and Val. This work provides a more convenient and flexible dual-mode sensing strategy for discriminating AA enantiomers, which is expected to be of great value in facile and high-throughput chiral recognition.

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Section: ■ Results and Discussionmentioning

confidence: 78%

Section: Resultsmentioning

confidence: 99%

Fluorescent/Colorimetric Dual-Mode Discriminating Gln and Val Enantiomers Based on Carbon Dots

Liao,

Wu,

et al. 2023

Anal. Chem.

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“…Numerous coating materials, including organic and inorganic compounds and materials, hybrid materials, and polymeric materials, have been introduced as physically adsorbed of chemically covalently attached SPs as shown in a previous review [165]. The recent reviews mostly deal with new SPs, such as microporous materials (MOFs [166, 167], covalent organic frameworks [168], porous organic cages, and knitted aromatic polymers, nanoparticles, polymer materials, silica‐based materials, and biomaterials). Various aspects of chiral CEC, including its history, advantages, bottlenecks, developments, and applications in the last 30 years and the future perspectives, were in detail discussed in a comprehensive review by Fanali and Chankvetadze [169].…”

Section: Separations By the Particular Ce Methodsmentioning

confidence: 99%

Recent developments in capillary and microchip electroseparations of peptides (2021–mid‐2023)

Kašička

2023

Electrophoresis

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This review article brings a comprehensive survey of developments and applications of high‐performance capillary and microchip electromigration methods (zone electrophoresis in a free solution or in sieving media, isotachophoresis, isoelectric focusing, affinity electrophoresis, electrokinetic chromatography, and electrochromatography) for analysis, micropreparation, and physicochemical characterization of peptides in the period from 2021 up to ca. the middle of 2023. Progress in the study of electromigration properties of peptides and various aspects of their analysis, such as sample preparation, adsorption suppression, electroosmotic flow regulation, and detection, are presented. New developments in the particular capillary electromigration methods are demonstrated, and several types of their applications are reported. They cover qualitative and quantitative analysis of synthetic or isolated peptides and determination of peptides in complex biomatrices, peptide profiling of biofluids and tissues, and monitoring of chemical and enzymatic reactions and physicochemical changes of peptides. They include also amino acid and sequence analysis of peptides, peptide mapping of proteins, separation of stereoisomers of peptides, and their chiral analyses. In addition, micropreparative separations and physicochemical characterization of peptides and their interactions with other (bio)molecules by the above CE methods are described.

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“…As a unique separation technology, capillary electrochromatography (CEC) combines the excellent separation efficiency of capillary electrophoresis (CE) with the exceptional selectivity of high-performance liquid chromatography (HPLC) [1]. CEC columns can be categorized into packed, monolithic, and open-tubular columns [2]. Among them, the open-tubular column has drawn the attention of numerous researchers due to its benefits, including straightforward preparation procedure, no frits needed, and good stability [2].…”

Section: Introductionmentioning

confidence: 99%

“…Among them, the open-tubular column has drawn the attention of numerous researchers due to its benefits, including straightforward preparation procedure, no frits needed, and good stability [2]. Recently, the stationary phase of open-tubular capillary electrochromatography (OT-CEC) has been mostly developed based on a variety of nanomaterials, such as graphene oxide [3], metal organic frameworks (MOFs) [4], biomaterials [5], and covalent organic frameworks (COFs) [2]. COFs, a new type of crystalline porous materials, is composed of covalently bound organic building blocks [6,7], and has the outstanding advantages including good chemical stability, tunable pore size, excellent thermal property, large surface area, and ease of modification.…”

Section: Introductionmentioning

confidence: 99%

In situ growth of imine‐based covalent organic framework as stationary phase for open‐tubular capillary electrochromatographic separation

Niu,

Qi,

Sun

et al. 2024

J of Separation Science

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Designing advanced stationary phases to improve separation efficiency is essential in capillary electrochromatography. Due to their outstanding performance, covalent organic frameworks have recently demonstrated considerable promise in the field of separation science. Herein, an open‐tubular capillary electrochromatography method was reported using porous imine‐based covalent organic framework with sufficiently available interaction sites as stationary phase. The imine‐based covalent organic framework coated capillary was easily prepared via an in situ growth method at room temperature, and its separation performance was evaluated, indicating the high separation efficiency for three types of analytes, including herbicides, polybrominated dibenzofurans, and bisphenols. Moreover, the imine‐based covalent organic framework coated capillary showed good reproducibility and stability, with intraday (n = 3), interday (n = 3), and column‐to‐column (n = 3) relative standard deviations of retention time and peak areas of less than 5%. The separation efficiency of the coated capillary remained unchanged even after 200 runs and the maximum theoretical plates reached up to 85 595 N/m for 4,4′‐ethylidenebisphenol. It was predicted that the imine‐based covalent organic framework stationary phase would be a strong contender for chromatographic separation with high efficiency.

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Synthesis of a covalent organic framework with hydrazine linkages and its application in open-tubular capillary electrochromatography

Cited by 22 publications

References 38 publications

Fluorescent/Colorimetric Dual-Mode Discriminating Gln and Val Enantiomers Based on Carbon Dots

Fluorescent/Colorimetric Dual-Mode Discriminating Gln and Val Enantiomers Based on Carbon Dots

Recent developments in capillary and microchip electroseparations of peptides (2021–mid‐2023)

In situ growth of imine‐based covalent organic framework as stationary phase for open‐tubular capillary electrochromatographic separation

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