Synthesis of 9H-furo [2,3-f]Chromene Derivatives by Promoting ZnO Nanoparticles

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In this study, a new, easy and high yield procedure is investigated for the generation of pyrazine containing pyrrolo[2,1‐a]isoquinoline derivatives using multicomponent reaction of phthalaldehyde or its derivatives, primary amines, α‐haloalketones, electron deficient acetylenic compounds, ammonium acetate and KF/Clinoptilolite nanoparticles (KF/CP NPs) as catalyst in water at room temperature. The reactions of 2‐hydroxy phthalaldehyde, primary amines, α‐haloketones, electron deficient acetylenic compounds, and ammonium acetate in the presence of KF/CP NPs as catalyst in water at room temperature produce pyrazine derivatives in good yields. Also, in this work, antioxidant ability was studied for a number of prepared compounds employing the 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging and power of compounds for reducing of ferric ion experiments and evaluating results with synthetic antioxidants (TBHQ and BHT). Comfortable, simple, fast and fresh procedure is the advantages of this study.

Section: Introductionmentioning

confidence: 99%

Green synthesis and investigation of antioxidant ability new pyrazines containing pyrrolo[2,1‐a]isoquinolines derivatives

Moghaddas

Hossaini

Zareyee

2020

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“…MCRs are very important in the synthesis of new drugs and agrochemicals. [ 19–26 ] In the multistep reaction generally due to multiple stages of separation of product, generate large amounts of waste that often involve the employ of pricey, poisonous, or unsafe solvents in all stage.…”

Section: Introductionmentioning

confidence: 99%

ZnO/Fe₃O₄ nanoparticles promoted green synthesis of pyrazolo pyrimidinones: Study of antioxidant activity

Ghoorchibeigi

Larijani

Azar

et al. 2020

The preparation of pyrazolo pyrimidinone derivatives was performed by using five component reactions of phthalaldehyde, cyanomethylamine, electron deficient acetylenic compounds, isocyanate, hydrazine, and catalytic amounts of ZnO/Fe 3 O 4-magnetic nanoparticles as a high performance catalyst under ultrasonic conditions at ambient temperature in aquause media at room temperature. It should be mentioned that this catalyst was prepared using Spinacia oleracea water extract. In addition, for investigation of antioxidant ability, radical trapping by DPPH and reducing power of ferric ion experiments was performed. As a result, synthesized compounds show excellent radical trapping by DPPH and good reducing ability of ferric ion. The current procedure has the benefits for instance excellent yield of reaction, green media, and easy separation of product and catalyst.

“…In continuation to our study for discovering new methods for the synthesis of important heterocyclic organic compounds, [ 53–59 ] we employed an effective four‐component reaction of isoquinoline 1 , α‐haloketones 2 , 2‐hydroxyacetophenone or its derivatives 3 , dimethyl carbonate 4 as green reagent, and catalytic amounts of PG ‐KF/CP NPs [ 50,51,57 ] in water at 80°C as a green procedure for the preparation of new pyrrolo isoquinoline derivatives, 5 , with excellent yields (Scheme 1) (see supporting information). In addition, because of the existing isoquinoline core in these products, the antioxidant ability of some pyrrolo isoquinolines was investigated by performing DPPH (2,2‐diphenyl‐1‐picrylhydrazyl) radical trapping and reducing the power of ferric ion evaluation.…”

Section: Introductionmentioning

confidence: 99%

Green synthesis of pyrrolo isoquinolines using in situ synthesis of 4‐hydroxycumarines: Study of antioxidant activity

Mousavi

Hossaini

Rostami‐Charati

et al. 2020

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In this research, synthesis of pyrrolo isoquinoline derivatives in excellent yields was performed using the multicomponent reaction of isoquinoline, alkyl bromides, 2‐hydroxyacetophenone, or its derivatives, dimethyl carbonate as a green reagent and KF/clinoptinolite nanoparticles as a catalyst in the aqueous media at 80°C. The Punica granatum peel water extract was used as the green media for the synthesis of PG‐KF/clinoptilolite nanoparticles in high yield. The PG‐KF/clinoptilolite nanoparticles show a significant basic catalytic role in these reactions in preparing the product in high yield and used for several times. In addition, for studying the antioxidant ability of some of the synthesized compounds, diphenyl‐picrylhydrazine (DPPH) radical trapping and power of ferric reduction tests are employed. The short time of the reaction, high yields of the product, easy separation of the catalyst and products are some of the advantages of this procedure.