ZnO/Fe₃O₄ nanoparticles promoted green synthesis of pyrazolo pyrimidinones: Study of antioxidant activity

Abstract

The preparation of pyrazolo pyrimidinone derivatives was performed by using five component reactions of phthalaldehyde, cyanomethylamine, electron deficient acetylenic compounds, isocyanate, hydrazine, and catalytic amounts of ZnO/Fe 3 O 4-magnetic nanoparticles as a high performance catalyst under ultrasonic conditions at ambient temperature in aquause media at room temperature. It should be mentioned that this catalyst was prepared using Spinacia oleracea water extract. In addition, for investigation of antioxidant ability, radical trapping by DPPH and reducing power of ferric ion experiments was performed. As a result, synthesized compounds show excellent radical trapping by DPPH and good reducing ability of ferric ion. The current procedure has the benefits for instance excellent yield of reaction, green media, and easy separation of product and catalyst.

Efficient Green Protocols for the Preparation of Pyrazolopyrimidines

“…The different derivatives synthesized based on this scheme are mentioned in Table 4. [29] Figure 3. A plausible mechanism for the synthesis of 3,7-diarylpyrazolo [1,5-a] pyrimidines, using ethanol and water as a green solvent.…”