Synthesis of [99mTc]ethyjenedicysteine-colchicine for evaluation of antiangiogenic effect

Zareneyrizi, Fereshteh; Yang, David J.; Oh, Chang Sok; Ilgan, Seyfettin; Yu, Dongfang; Tansey, Wayne; Liu, Chun Wei; Kim, E. Edmund; Podoloff, Donald A.

doi:10.1097/00001813-199908000-00009

Cited by 40 publications

(25 citation statements)

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“…99m Tc-ethylenedicysteine ( 99m Tc-EC) is a successful example of N 2 S 2 chelates. Using a standard coupling technique, 99m Tc-EC-drug conjugates were then developed to characterize tumor tissues (15,16). In the previous report, we have described in vivo biodistribution and planar imaging studies in tumor-bearing rats given 99m Tc-EC annexin V ( 99m Tc-EC-ANX), and have demonstrated the pharmacokinetic distribution of the tracer and feasibility of using 99m Tc-EC-ANX to image apoptosis-induced tumor (17).…”

Section: Introductionmentioning

confidence: 99%

Imaging and dosimetry of 99mTc EC annexin V: Preliminary clinical study targeting apoptosis in breast tumors

Kurihara

Yang

Cristofanilli

et al. 2008

Applied Radiation and Isotopes

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Section: Introductionmentioning

confidence: 99%

Imaging and dosimetry of 99mTc EC annexin V: Preliminary clinical study targeting apoptosis in breast tumors

Kurihara

Yang

Cristofanilli

et al. 2008

Applied Radiation and Isotopes

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“…Tc efficiently with high radiochemical purity and the preparation remains stable for several hours [12][13][14][15][16][17][18][19][20][21][22].…”

Section: Ga and 99mmentioning

confidence: 99%

Tumor Specific Imaging Using Tc-99m and Ga-68 Labeled Radiopharmaceuticals

Yang¹,

Azhdarinia²,

Kim³

2005

CMIR

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Improvement of scintigraphic tumor imaging is extensively determined by the development of more tumor specific radiopharmaceuticals. Thus, to improve the differential diagnosis, prognosis, planning and monitoring of cancer treatment, several functional pharmaceuticals have been developed. Application of molecular targets for cancer imaging, therapy and prevention using generator-produced isotopes are the major focus of ongoing research projects. Radionuclide imaging modalities (positron emission tomography, PET; single photon emission computed tomography, SPECT) are diagnostic cross-sectional imaging techniques that map the location and concentration of radionuclide-labeled radiotracers.99m Tc-and 68 Ga-labeled agents using ethylenedicysteine (EC) as a chelator were synthesized and their potential uses to assess tumor targets were evaluated.99m Tc (t 1/2 =6 hr, 140 keV) is used for SPECT and 68 Ga (t 1/2 =68 min, 511 keV) is for PET. Molecular targets labeled with Tc-99m and Ga-68 can be utilized for prediction of therapeutic response, monitoring tumor response to treatment and differential diagnosis. Molecular targets for oncological research in (1) cell apoptosis, (2) gene and nucleic acid-based approach, (3) angiogenesis (4) tumor hypoxia, and (5) metabolic imaging are discussed. Numerous imaging ligands in these categories have been developed and evaluated in animals and humans. Molecular targets were imaged and their potential to redirect optimal cancer diagnosis and therapeutics were demonstrated.

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“…2,3 5 They were used in targeting tumors and reported to exhibit good tumor uptake. 4,5 The present work deals with the labeling of colchicine by iodine -125 to study the factors, which affect the radiochemical yield. The labeled compound is purified by using HPLC for studying the biodistribution in normal mice.…”

Section: Introductionmentioning

confidence: 99%

An investigation of the ¹²⁵I‐radioiodination of colchicine for medical purposes

El-Azony

El-Mohty

Killa

et al. 2008

Labelled Comp Radiopharmac

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A procedure for radioiodination of colchicine with iodine-125 is carried out via an electrophilic substitution reaction. The reaction parameters studied were colchicine concentration, pH of the reaction mixture, reaction time, temperature, different oxidizing agents and different organic media to optimize the conditions for the labeling of colchicine and to obtain a high radiochemical yield of the 125 I-colchicine ( 125 I-Col). Using 3.7 MBq of Na

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Synthesis of [99mTc]ethyjenedicysteine-colchicine for evaluation of antiangiogenic effect

Cited by 40 publications

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Imaging and dosimetry of 99mTc EC annexin V: Preliminary clinical study targeting apoptosis in breast tumors

Imaging and dosimetry of 99mTc EC annexin V: Preliminary clinical study targeting apoptosis in breast tumors

Tumor Specific Imaging Using Tc-99m and Ga-68 Labeled Radiopharmaceuticals

An investigation of the ¹²⁵I‐radioiodination of colchicine for medical purposes

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Synthesis of [99mTc]ethyjenedicysteine-colchicine for evaluation of antiangiogenic effect

Cited by 40 publications

References 0 publications

Imaging and dosimetry of 99mTc EC annexin V: Preliminary clinical study targeting apoptosis in breast tumors

Imaging and dosimetry of 99mTc EC annexin V: Preliminary clinical study targeting apoptosis in breast tumors

Tumor Specific Imaging Using Tc-99m and Ga-68 Labeled Radiopharmaceuticals

An investigation of the 125I‐radioiodination of colchicine for medical purposes

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An investigation of the ¹²⁵I‐radioiodination of colchicine for medical purposes