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A procedure for radioiodination of colchicine with iodine-125 is carried out via an electrophilic substitution reaction. The reaction parameters studied were colchicine concentration, pH of the reaction mixture, reaction time, temperature, different oxidizing agents and different organic media to optimize the conditions for the labeling of colchicine and to obtain a high radiochemical yield of the 125 I-colchicine ( 125 I-Col). Using 3.7 MBq of Na

Methods are described for the determination of selenols (RSeH), diselenides (RSeSeR), and selenenyl sulfides (RSeSR'). The methods are based on the separation of the selenium-containing compounds by reversed-phase liquid chromatography followed by detection with an electrochemical detector with dual Hg/Au amalgam electrodes In series In the eluent stream. Selenols are detected directly by facilitation of the oxidation of Hg from the downstream electrode when It Is set to +0.150 V vs the Ag/AgCI reference elec-