“…A heating-promoted annulation of CF 3 -imidoyl sulfoxonium ylides and α-enolic dithioesters under catalyst- and additive-free conditions was achieved by Cheng, Yang and co-workers, which provided a facile approach for the assembly of 4-(trifluoromethyl)-2,3-dihydrothiazoles (Scheme 50). 63 α-Enolic dithioesters, as a kind of versatile sulfur-containing synthons with several nucleophilic and electrophilic reactive sites, have been utilized to construct various heterocycles. Inspired by Cheng's work involving the reaction of TFISYs with 1,3-dicarbonyl compounds, α-enolic dithioesters with the similar structure reacted with TFISYs under only thermal conditions to yield the unexpected 4-(trifluoromethyl)-2,3-dihydrothiazole products.…”