Synthesis of 3-Azabicyclo[3.3.1]nonane-6,9-diones

Morpholine

“…Furthermore, bis-electrophilic agents such as Acryloyl Chloride can react with the morpholino enamine of N-carboxy-4-piperidones, thereby providing access to bicyclo[3.3.1]nonane-6,9-diones (eq 24). 36 Compared to reactions with pyrrolidino or piperidino enamines, morpholino enamines give better yields.…”