Synthesis of 3-Aryl Coumarin Derivatives  Using Ultrasound

Sripathi, Shubashini K.; Logeeswari, Kandasamy

doi:10.4236/ijoc.2013.31004

Cited by 18 publications

(12 citation statements)

References 19 publications

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“…Ultrasound irradiation technique is also useful to synthesize 3-aryl coumarin derivatives. Treatment of o-hydroxybenzaldehydes 18 with aryl substituted acetyl chloride 27 in the presence of K 2 CO 3 as a catalyst in tetrahydrofuran (THF) using ultrasound irradiation leads to the formation of 3-aryl coumarin derivatives 28 in moderate to high yields (Figure 8) [83]. This green method appears to be a convenient and simple pathway than that of conventional heating.…”

Section: Methods To Synthesize Coumarin Derivatives 21 Pechmann Condmentioning

confidence: 99%

One-Pot Synthesis of Coumarin Derivatives

Ansary¹,

Taher²

2020

Phytochemicals in Human Health

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Coumarin derivatives have a myriad of applications in medical science, biomedical research, and many industrial branches. For this reason, many efforts are being dedicated to the development of novel and more practical methods for synthesizing these compounds. This chapter describes several methods of one-pot synthesis of coumarin derivatives, including von Pechmann condensation, Knoevenagel condensation, Baylis-Hillman reaction, Michael addition, Kostanecki reaction, vinyl phosphonium salt-mediated electrophilic reaction, and Heck-lactonization reaction. The methods are compared with each other, and the advantages and disadvantages of each of them are addressed.

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Section: Methods To Synthesize Coumarin Derivatives 21 Pechmann Condmentioning

confidence: 99%

One-Pot Synthesis of Coumarin Derivatives

Ansary¹,

Taher²

2020

Phytochemicals in Human Health

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“…Yields of obtained products under that reaction conditions were in the range from 41 to 98%. Sripathi and Logeeswari reported synthesis of 3-aryl lcoumarin derivatives using ultrasonic irradiation [88]. 3-Phenylcoumarins were synthesized from salicylaldehydes and phenyl acetyl chloride with the addition of tetrahydrofuran (THF) and K2CO3 (Scheme 29).…”

Section: Scheme 15 Synthesis Of Coumarin-3-carboxylic Esters In Multmentioning

confidence: 99%

Recent Advances in the Synthesis of Coumarin Derivatives from Different Starting Materials

et al. 2020

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The study of coumarin dates back to 1820 when coumarin was first extracted from tonka bean by Vogel. Compounds containing coumarin backbone are a very important group of compounds due to their usage in pharmacy and medicine. Properties and biological activities of coumarin derivatives have a significant role in the development of new drugs. Therefore, many different methods and techniques are developed in order to synthesize coumarin derivatives. Coumarin derivatives could be obtained from different starting materials with various methods but with big differences in yield. This review summarized various methods, techniques and reaction conditions for synthesis of coumarins from different compounds such as aldehydes, phenols, ketones and carboxylic acids.

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“…[23][24][25] Because of these high profile applications, widespread studies for the synthesis of coumarins have promoted. [26][27][28] 4H-Pyrans are important building blocks in an extensive number of biologically active compounds. [29] In addition, they are ubiquitous in broad spectrum of natural products.…”

Section: Introductionmentioning

confidence: 99%

“…[ 23–25 ] Because of these high profile applications, widespread studies for the synthesis of coumarins have promoted. [ 26–28 ]…”

Section: Introductionmentioning

confidence: 99%

A green, facile, and one‐pot synthesis of 2‐amino‐4H‐pyran derivatives using tungstate sulfuric acid as a solid acid catalyst

Rohani

Karami

Farahi

2020

J Chinese Chemical Soc

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2-Amino-4H-pyran-3-carbonitriles and 2-amino-4H-pyran-3-carboxylate derivatives were synthesized under mild conditions in the presence of tungstate sulfuric acid (TSA) as a recyclable solid acid catalyst. Catalytic condensation between 3-acetylcoumarin, aromatic aldehydes, and malononitrile or ethyl cyanoacetate gave the 2-amino-4H-pyran derivatives. Tungstate sulfuric acid is a low-cost, nontoxic, and reusable catalyst, which does not require very high temperatures and good to excellent yields were obtained in all cases. The catalyst can be reused for many times without significant loss of its activity. K E Y W O R D S2-amino-4-H-pyran, 3-acetylcoumarin, aromatic aldehydes, ethyl cyanoacetate, malononitrile

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Synthesis of 3-Aryl Coumarin Derivatives Using Ultrasound

Cited by 18 publications

References 19 publications

One-Pot Synthesis of Coumarin Derivatives

One-Pot Synthesis of Coumarin Derivatives

Recent Advances in the Synthesis of Coumarin Derivatives from Different Starting Materials

A green, facile, and one‐pot synthesis of 2‐amino‐4H‐pyran derivatives using tungstate sulfuric acid as a solid acid catalyst

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