Synthesis of 3‐(6‐Aryl‐pyridin‐2‐yl)‐ and 8‐(6‐Aryl‐pyridin‐2‐yl) Coumarins

Brahmbhatt, D. I.; Gajera, Jitendra M.; Pandya, V. P.; Patel, Mohan N.

doi:10.1002/chin.200737140

Cited by 3 publications

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“…Mannich base 119 of 3-acetylcoumarin 1 was prepared via condensation of the corresponding acetylcoumarin 1 with paraformaldehyde 117 and dimethylamine 118 in the presence of conc. HCl (Scheme 21) 62 . The reaction of 119 with substituted phenacylpyridiniumbromide salts 120 in the presence of ammonium acetate in refluxing acetic acid gave the corresponding 3-(6-arylpyridin-2-yl) 121 in moderate to good yields (scheme 21).…”

Section: Mannich Reactionmentioning

confidence: 99%

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3-Acyl(aroyl)coumarins as synthon in heterocyclic synthesis

Hamama¹,

Berghot²,

Baz³

et al. 2019

Org.Commun.

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Section: Mannich Reactionmentioning

confidence: 99%

“…The reaction of 119 with substituted phenacylpyridiniumbromide salts 120 in the presence of ammonium acetate in refluxing acetic acid gave the corresponding 3-(6-arylpyridin-2-yl) 121 in moderate to good yields (scheme 21). 62…”

Section: Mannich Reactionmentioning

confidence: 99%

3-Acyl(aroyl)coumarins as synthon in heterocyclic synthesis

Hamama¹,

Berghot²,

Baz³

et al. 2019

Org.Commun.

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“…Especially, the characteristics of the main coumarin compounds vary considerably by connecting the appropriate components into them. Thus, they may be converted to more useful and relevant products in different fields of science and technology (4). Because of their π-conjugated structures, coumarins and derivatives exhibit significant and unique photophysical and spectroscopic properties (5).…”

Section: Introductionmentioning

confidence: 99%

A Study on the Optoelectronic Parameters of 4-Chloromethyl-7-Hydroxy Coumarin in Various Solvents and Concentrations

Kurt

Gündüz

Koca

2021

Journal of the Turkish Chemical Society Section A: Chemistry

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A coumarin derivative, namely 4-chloromethyl-7-hydroxy coumarin (CMEHC), was synthesized in order to test the concentration and solvent effect on its optical properties. The spectral characterization of this compound was accomplished by FTIR and 1 H-NMR techniques. The UV absorption spectra of CMEHC compound in various solvents (THF, DMSO, DMF) were recorded with a UV-VIS spectrophotometer. The optical parameters such as maximum peak position, absorption band edge, and direct allowed bandgap were reported for these solvents and also various concentrations. The lowest direct allowed bandgap was obtained with THF. The absorbance spectra of CMEHC compound were dominant at the near ultraviolet region. The refractive index values were compared with each other using Moss, Ravindra, Herve-Vandamme, Reddy and Kumar-Singh relations.

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“…They are the family of lactones containing benzopyrone skeletal framework that have enjoyed isolation from plant as well as total synthesis in the laboratory 2 . The incorporation of other heterocyclic moiety either as substituent group or as a fused component into the parent coumarin alters the property of parent coumarin and converts it into a more useful product 3 . Coumarins are plant flavonoids widely distributed in nature.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Evaluation of Some New Coumarin Derivatives as Antimicrobial Agents

Youssif

2013

Bulletin of Pharmaceutical Sciences. Assiut

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The purity of all new compounds was checked by TLC and elucidation of their structures was confirmed by IR, 1 H NMR, and mass spectrometry along with elemental microanalyses. All the target compounds were evaluated for their possible antimicrobial activity. Most of the tested compounds showed weak to moderate antibacterial activity against most of the bacterial strains used in comparison with gatifloxacin as a reference drug. The most active compounds were 6b, 6c, 7b, 8b, 8c, and 9c against B. cereus, E. coli and S. marcescens. Results of antifungal activity revealed that all compounds showed weak to moderate activity against S. brevicaulis, while ketoconazole as a reference drug was completely inactive . Compounds 6a, 6b, 6c, 6e and 7b were even more active than ketoconazole against F. oxysporum.

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Synthesis of 3‐(6‐Aryl‐pyridin‐2‐yl)‐ and 8‐(6‐Aryl‐pyridin‐2‐yl) Coumarins

Abstract: Synthesis of 3-(6-Aryl-pyridin-2-yl)-and 8-(6-Aryl-pyridin-2-yl) Coumarins -[via reaction of Mannich bases derived from acetylcoumarins with pyridinium salts (II) under Kroehnke-type reaction conditions]. -(BRAHMBHATT*, D. I.; GAJERA, J. M.; PANDYA, V. P.; PATEL, M. A.; Indian J.

Cited by 3 publications

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3-Acyl(aroyl)coumarins as synthon in heterocyclic synthesis

3-Acyl(aroyl)coumarins as synthon in heterocyclic synthesis

A Study on the Optoelectronic Parameters of 4-Chloromethyl-7-Hydroxy Coumarin in Various Solvents and Concentrations

Synthesis and Biological Evaluation of Some New Coumarin Derivatives as Antimicrobial Agents

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