Synthesis of [3-14C]-L-tryptophan and 5′-hydroxy-[3-14C]-L-tryptophan

Winnicka, Elżbieta; Kańska, Marianna

doi:10.1007/s10967-008-7415-0

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2018

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Cited by 2 publications

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“…In the same manner the isotopomers of [3- 14 C]- l -Trp ( 29k ) and 5-OH-[3- 14 C]- l -Trp ( 32e ) were obtained in one-pot multienzymatic synthesis in presence of the same four enzymes as above, and by using as substrates [3- 14 C]- dl -alanine ( 33a ) and indole ( 30 ) or 5-hydroxyindole ( 31 ) respectively [111] (Fig. 26).…”

Section: Synthesismentioning

confidence: 99%

The chemo- enzymatic synthesis of labeled l-amino acids and some of their derivatives

Pająk

Pałka

Winnicka

et al. 2018

J Radioanal Nucl Chem

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This review compiles the combined chemical and enzymatic synthesis of aromatic l-amino acids (l-phenylalanine, l-tyrosine, l-DOPA, l-tryptophan, and their derivatives and precursors) specifically labeled with carbon and hydrogen isotopes, which were elaborated in our research group by the past 20 years. These compounds could be then employed to characterize the mechanisms of enzymatic reactions via kinetic and solvent isotope effects methods.

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Section: Synthesismentioning

confidence: 99%