Synthesis of 2-sulfanyl-6-methyl-1,4-dihydropyrimidines as a new class of antifilarial agents

Synthesis, Structural Elucidation and Anti-Microbial Screening of Benzimidazole Incorporated S-Triazinyl Derivatives

“…Literature survey reveals that substituted s-triazine derivatives are associated with a number of pronounced biological activities [1][2][3][4] . The biological activity is a function of physicochemical properties of the targeted molecule and this assessment is based on the kinds of chemicals that might fit into an active site 5,6 .…”

In vitro antimycobacterial activity of novel N′-(4-(substituted phenyl amino)-6-(pyridin-2-ylamino)-1,3,5-triazin-2-yl)isonicotinohydrazide

“…Literature survey reveals that substituted s-triazine derivatives are associated with a number of pronounced biological activities Desai, 2004, Patel et al, 2007;Kumar et al, 2008;Singh et al, 2008). The biological activity is a function of physicochemical properties of the targeted molecule, and this assessment is based on the kinds of chemicals that might fit into an active site (Gubernator and Bohm, 1998;Weiner and William, 1994).…”

One-pot three-component synthesis of 4-aryl-3,4-dihydro-pyrimidin-2(1<i>H</i>)-thiones catalyzed by Ni loaded SiO₂

“…However, this method often suffers from drawbacks such as harsh conditions, long reaction times and low yields, particularly when aliphatic and substituted aromatic aldehydes are used. Recently, several synthetic procedures for preparing of DHPMs have been reported, such as the use of a number of Lewis acid catalysts as well as protic acids including Y(NO 3 ) 3 .6H 2 O [8], Cu(BF 4 ) 2 [9], KAl(SO 4 ) 2 .12H 2 O [10], Mg(ClO 4 ) 2 [11], triphenylphosphine [12], Ca(NO 3 ) 2 [13], and H 3 BO 3 [14]. In addition, microwave irradiation [15], ultrasound irradiation [16], and ionic liquid [17] have also been utilized to improve and modify this reaction.…”

“…In recent years, dihydropyrimidinones (DHPMs) and their derivatives have occupied an important position in natural and synthetic organic chemistry because of their wide range of biological activities, such as calcium channel blockers, antiviral, antihypertensive, antifilarial, antibacterial [1][2][3][4], and antagonists [5]. Several alkaloids which contain the dihydropyrimidine core unit that have been isolated from marine sources also showed interesting biological properties.…”