In vitro antimycobacterial activity of novel N′-(4-(substituted phenyl amino)-6-(pyridin-2-ylamino)-1,3,5-triazin-2-yl)isonicotinohydrazide

Abstract

A variety of N 0 -(4-(substituted phenyl amino)-6-(pyridin-2-ylamino)-1,3,5-triazin-2-yl)isonicotinohydrazide, 7a-r were synthesized by using 2-aminopyridine, isonicotic acid hydrazide and cyanuric chloride, and the structures of these compounds were confirmed by IR and NMR ( 1 H and 13 C) spectral analyses. Newly synthesized compounds were tested for their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system.

Synthesis, Characterization, and Tautomerism of 1,3-Dimethyl Pyrimidine-2,4,6-Trione s-Triazinyl Hydrazine/Hydrazone Derivatives

“…1,3,5-Triazine or s-triazine belongs to the group of heterocyclic compounds having significant applications within pharmaceuticals, textile, rubber, and plastics industries, and as polymer photostabilizers, herbicides, dyestuffs, optical bleaches, explosives, and surface active agents [1,2]. Several derivatives of s-triazine have exhibited antimicrobial [3], antibacterial [4], antifungal [3], anti-HIV [5], anticancer [6,7], and a wide range of other biological activities [8][9][10]. Recently some of 1,3,5-triazine-Schiff base exhibited some activity against Mycobacterium tuberculosis H37Rv [11] and moderate to excellent antiproliferative activity with high selectivity against the human lung cancer cell line H460 [12,13].…”

“…Herein, we report the synthesis of novel class of s-triazine-pyrimidinetrione hydrazone derivatives and their tautomeric behavior as well. 3 and/or DMSO-d 6 using internal standard = 0 ppm. Elemental analysis were performed on Perkin-Elmer 2400 elemental analyzer.…”

Synthesis, characterization and antimicrobial activity of novel 2,5-substituted aryl-7-phenyl-1,3,4-oxadiazolo-[3,2-a]-1,3,5-triazine derivatives

“…The zone of inhibition were measured for all synthesized compounds. [28][29] IJBR (2014) 05 (01) www.ssjournals.com…”

Synthesis, characterization and crystal structures of hydrazone compounds derived from isonicotinohydrazide

“…It can react with aldehydes to form isonicotinohydrazones, which show interesting biological activities [1][2][3][4]. Moreover, isonicotinohydrazone compounds usually possess three or more donor atoms, which can readily form complexes with various metal atoms [5][6][7][8][9][10][11][12].…”

“…Study on the synthesis and structures of such compounds are important for medicinal chemistry. In the present work, two new isonicotinohydrazone compounds, N'- (3-bromobenzylidene)isonicotinohydrazide (1) and N'-(2,3-difluorobenzylidene)isonicotinohydrazide (2), were prepared and structurally characterized.…”