We
disclose the first catalytic domino reaction of α-(2-formylaryloxy)acetonitriles
with arylboronic acids, yielding a range of 2-aroylbenzo[b]furans with yields of up to 93%. Ni(acac)2 serves as
an effective dual catalyst. The protocol is also applicable to α-(2-acetylphenoxy)acetonitrile,
giving rise to 3-methyl-2-aroylbenzo[b]furans. This
domino process is efficient, additive-free, and compatible with a
variety of aryl boronic acids, including those with CF3, NO2, CN, and CO2Me groups. Mechanistic studies
highlight the dual activation facilitated by the nickel catalyst.