Palladium(II)-Catalyzed Intramolecular Tandem Cyclization Reaction for the Assembly of Unsymmetrical 2,6-Disubstituted Pyrazines

Abstract

An efficient synthesis of unsymmetrical 2,6-disubstituted pyrazines was developed via a palladium(II)-catalyzed cascade reaction from aminoacetonitriles and arylboronic acids. This transformation involves a C(sp)-C(sp2) coupling followed by an intramolecular C-N bond formation in good to excellent yields.