Synthesis of 2-(alkylamino)-5-{alkyl[(2-oxo-2H-chromen-3-yl)carbonyl]amino}-3,4-furandicarboxylates using a multi-component reaction in water

Bi‐SO3H Functionalized Ionic Liquid Based on DABCO: New and Efficient Catalyst for Facile Synthesis of Dihydropyrimidinones

“…MCRs allow the creation of several bonds in a single operation and offer remarkable advantages like simple procedure, high bond forming efficiency, time and energy saving, extraction and purification processes, and hence minimize waste generation [6][7][8][9][10]. MCRs are useful for the expedient creation of chemical libraries of drug-like compounds with high levels of molecular complexity and diversity, thereby facilitating identification/optimization in drug discovery programmes [11][12][13][14][15][16]. Therefore, researchers have made great efforts to develop new MCRs with green procedure, especially in the areas of drug discovery, organic synthesis, and material science [17,18].…”

Evaluation of Biodegradable Glucose Based Surfactants as a Promoting Medium for the Synthesis of Peptidomimetics with the Coumarin Scaffold

“…For example Sheikhhosseini et al have developed the synthesis of 3-substitued coumarin-3-carboxamides. [12] Furthermore, the preparation of coumarin-3-carboxamides containing a triazole ring was described by Shaabani et al [13] Balalaie et al showed the synthesis of coumarin-3-carboxamides containing lipophilic spacers, [14] and 2-(alkylamino)-5-(alkylcoumarin-3-carbonyl)amino-3,4furan-dicarboxylates were synthetized by Adib et al [15] Mentioned examples demonstrate that there is a great interest of engaging MCRs for the synthesis of compounds with coumarin scaffold. Although the P-MCR is typically performed in aprotic organic solvents, there are numerous examples of P-MCR performed in water.…”

An efficient domino one-pot synthesis of novel spirofuran-indenoquinoxalines by vinyltriphenylphosphonium salts

“…Spiroheterocycles are also particularly interesting due to the presence of a spirocarbon which provides a strengthening of the structure 19,22,23 and, together with a diversity of furanes, is the main important core of many pharmacological agents. 2,24 In this context, spirolactone derivatives have been reported as anti-convulsants and antitumorals. [25][26][27] Further, quinoxaline derivatives are an important group of nitrogen-containing heterocycles displaying a broad spectrum of biological activities which have made them privileged structures in pharmacologically active compounds.…”