A series of novel b-lactams was synthesized from different imines and a special ketene derived from Nendo-5-norbornene-2,3-dicarboxyloylglycine 1 via the [2 ? 2] ketene imine cycloaddition. Then, b-lactams 3a-h were treated with 1-azido-4-nitrobenzene 4 to afford blactam-triazole hybrids 5a-h. Of the twenty-three b-lactams tested against chloroquine-resistant P. falciparum K14 strain, 3a and 3d showed IC 50 \ 20 lM, while 3j, 3m, 5a-5f exhibited IC 50 \ 50. These newly synthesized blactams were also tested against S. aureus, E. coli, P. aeruginosa, C. albicans and C. glabrata and showed no activity below 125 lg/mL.