Synthesis of 16-mercaptohexadecylphosphocholine, a miltefosine analog with leishmanicidal activity

Hornillos, Valentı́n; Saugar, José María; Torre, Beatriz G. de la; Andreu, David; Rivas, Luís; Acuña, A. Ulises; Amat‐Guerri, F.

doi:10.1016/j.bmcl.2006.07.004

Cited by 14 publications

(12 citation statements)

References 32 publications

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“…HPC and other APCs or alkyllysophospholipids are active against more parasites than merely P. falciparum. They also exhibit antiprotozoal activity on Leishmania [43][44][45][46][47], Acanthamoeba [48][49][50][51], Balamuthia, Negleria [52], Trichomonas [53] or Enthamoeba [54], and Trypanosoma [55]. APCs possess also antimycotic [35,56], antineoplastic [51,57,58], and antiviral activities [59].…”

Section: Introductionmentioning

confidence: 97%

Surface-active properties of nitrogen heterocyclic and dialkylamino derivates of hexadecylphosphocholine and cetyltrimethylammonium bromide

Lukáč¹,

Pisárčik²,

Lacko³

et al. 2010

Journal of Colloid and Interface Science

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Section: Introductionmentioning

confidence: 97%

Surface-active properties of nitrogen heterocyclic and dialkylamino derivates of hexadecylphosphocholine and cetyltrimethylammonium bromide

Lukáč¹,

Pisárčik²,

Lacko³

et al. 2010

Journal of Colloid and Interface Science

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“…In all subsequent assays, the upper limit of the dose range 379 tested was either the highest non-toxic dose or the lowest toxic dose determined in this There are many protocols in the literature for the synthesis of alkylphospholipid 414 analogues [33,34]. The best procedure we had access to was using the calcium salt of 415 phosphorylcholine 1 as starting material (Scheme 1).…”

Section: Cytokinesis-block Micronucleus Assay (Chromosomal Mutation Amentioning

confidence: 99%

Leishmanicidal, antiproteolytic, and mutagenic evaluation of alkyltriazoles and alkylphosphocholines

Gontijo

Espuri

Alves

et al. 2015

European Journal of Medicinal Chemistry

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“…Phosphocholine analog: (Figure 2) Miltefosine (MT): (Impavido) (n-hexadecylphosphocholine) MT is an alky-lphosphocholine (ALP) imitative which was previous used as an anticancer drug [3,17] but nowadays castoff as antileishmanial drug, i.e., operative against both CL and VL (oral treatment.) [3,18]. It is used in opposition to antimony resistant parasites [12,18].…”

Section: 5 Azole Derivativesmentioning

confidence: 99%

Chemotherapy of Leishmaniasis – A Review

Borah¹,

Biswajit²,

Dash³

2017

Asian J Pharm Clin Res

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Leishmaniasis is a dismissed vector-borne tropical contamination thought to be an ailment of poor people. It is a standout among the most ignored tropical sickness as far as medication disclosure and improvement. Moved in neediness stricken nations inside Southeast Asia, East Africa, and Latin America, it is likewise endemic in a few Mediterranean nations. The administration of the heterogeneous disorders controlled by parasites having a place with the genus Leishmania is, especially troublesome in created, non-endemic nations attributable to the newness of doctors with clinical side effects, demonstrative conceivable outcomes, and accessible treatment choices. Most antileishmanial medications are very lethal and introduce resistance issues or require hospitalization, being along these lines not sufficient to the field. As of late changes have been accomplished by blend treatment, decreasing the time, and cost of treatment. Regardless, new medications are still direly required. This overview highlights the chemotherapeutic operators against leishmaniasis, their science, method of activity and the component of resistance in the parasite. Future viewpoints in the territory of new hostile to leishmanial sedate targets are likewise specified.

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Synthesis of 16-mercaptohexadecylphosphocholine, a miltefosine analog with leishmanicidal activity

Cited by 14 publications

References 32 publications

Surface-active properties of nitrogen heterocyclic and dialkylamino derivates of hexadecylphosphocholine and cetyltrimethylammonium bromide

Surface-active properties of nitrogen heterocyclic and dialkylamino derivates of hexadecylphosphocholine and cetyltrimethylammonium bromide

Leishmanicidal, antiproteolytic, and mutagenic evaluation of alkyltriazoles and alkylphosphocholines

Chemotherapy of Leishmaniasis – A Review

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