Synthesis of 15P-conjugated PPy-modified gold nanoparticles and their application to photothermal therapy of ovarian cancer

Wang, Li; Wang, Liping; Xu, Tianshu; Guo, Chengjun; Liu, Chuanzhi; Zhang, Hao; Li, Jing; Liang, Zhiqing

doi:10.1007/s40242-014-4039-5

Cited by 4 publications

(2 citation statements)

References 27 publications

(26 reference statements)

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“…In the recent decade, photothermal treatment has attracted great attention as a promising avenue for cancer therapy, which makes use of the photothermal effect of the inorganic nanoparticles such as silica/gold nanoshells 1 , 2 , gold nanorods 3 , 4 , gold nanospheres 5 , 6 , gold nanocages 7 , 8 , gold nanostars 9 , 10 , or carbon nanotubes 11 , 12 . These nanomaterials are administrated by intravenous or intra-tumor injection with subsequent irradiation of laser light to raise the temperature to kill the tumor cells.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic albumin-modified gold nanorods for photothermo-chemotherapy and macrophage polarization modulation

Zhang

et al. 2018

Acta Pharmaceutica Sinica B

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Nanotechnology-based photothermal therapy has attracted great attention in the past decade. Nevertheless, photothermal therapy has some inherent drawbacks, such as the uneven heat production and limited laser penetration, often leading to insufficient treatment outcomes. Here, we developed a combination strategy to improve cancer therapy. The biomimetic albumin-modified gold nanorods (AuNRs) were prepared with incorporation of paclitaxel (PTX). This therapeutic system was characterized by several features. First, the albumin modification enhanced the biocompatibility and colloidal stability. Second, the surface-coated albumin promoted cellular uptake via the albumin-binding protein pathway. Third, PTX was incorporated via hydrophobic interaction between PTX and the albumin lipophilic domain. Fourth, the system can be used for combined photothermo-chemotherapy for yielding synergistic effects. The antitumor activity of the system was evaluated both in vitro and in vivo using the HCT116 colon cancer cell and tumor model. The combination therapy was found with an enhanced treatment efficiency and no obvious side effect. Most importantly, the thermal effect was also discovered with the ability to modulate the tumor microenvironments and suppress the macrophages polarization towards the M2 pro-tumor phenotype. It could be a mechanism for photothermal immunotherapy. The combination strategy and the system provide a potential method for cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Biomimetic albumin-modified gold nanorods for photothermo-chemotherapy and macrophage polarization modulation

Zhang

et al. 2018

Acta Pharmaceutica Sinica B

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“…The 15-polypeptide for tumor targeting is made by SHSWHWLPNLRHYAS amino acids [20]. The gold seeds were synthesized using the method described by Liwei Liu in 2011 [21].…”

Section: Synthesis Of Bio-compatible Gnr and 15p-gnrsmentioning

confidence: 99%

Application of Gold Nanorods for Photothermal Therapy

Liu¹,

Gong²,

Liang³

et al. 2020

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Photothermal therapy is a treatment method which used a material with a high conversion efficiency of field or biological synthetic material, using target recognition technology gathered near the cancer tissues after injected into human bodies, with near-infrared convert light energy into heat energy to kill cancer. Here reported the biocompatible use of gold nanorods(GRNs) as probes for cancer targeting in vitro. More specifically, this paper demonstrated a progressive synthesis approach in fabricating water-dispersible gold nanorods. These nanorods were prepared by replacing cetyltrimethylammonium bromide with a mixture of 15-polypeptide(15P) molecules, such that a variety of cell viability assays did not reveal any signals of toxicity in the treated cells. The samples size was estimated to be 70-80 nm; Dynamic light scattering reveals that the cores of the gold nanorods are protected from the outside environment by the 15-polypeptide. Photothermal treatment indicated that 15P-GNRs can stain tumor growth and devoted the pivotal steps in promoting of the use of ternary GNRs as a tumor targeting, more importantly, these results suggest that 15P-GNRs can serve as biocompatible synthetic material and multimodal platform for various bio-applications and the micelle-encapsulated nanoparticles formulation was able to target the tumor site directly. On the other hand, Photothermal therapy has great effect in killing cancer cell with near-infrared.

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Inorganic material based macrophage regulation for cancer therapy: basic concepts and recent advances

et al. 2021

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Synthesis of 15P-conjugated PPy-modified gold nanoparticles and their application to photothermal therapy of ovarian cancer

Cited by 4 publications

References 27 publications

Biomimetic albumin-modified gold nanorods for photothermo-chemotherapy and macrophage polarization modulation

Biomimetic albumin-modified gold nanorods for photothermo-chemotherapy and macrophage polarization modulation

Application of Gold Nanorods for Photothermal Therapy

Inorganic material based macrophage regulation for cancer therapy: basic concepts and recent advances

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