Synthesis of 1,4-Benzodiazepine- 2,5-dione Derivatives

N-(2-Methylphenyl)-2-nitrobenzamide

“…The benzanilide core is present in compounds with such a wide range of biological activities that it has been called a privileged structure. Benzanilides serve as intermediates towards benzothiadiazin-4-ones (Makino et al, 2003), quinazoline-2,4-diones (Makino et al, 2001) and benzodiazepine-2,5-diones (Ho et al, 2002) and 110 kinase inhibitors 2,3-disubstituted 3H-quinazoline-4-ones (Zhichkin et al, 2007). Benzanilides have established their efficacy as centroid elements of ligands that bind to a wide variety of receptor types.…”

N-(3-Chlorophenyl)-2-nitrobenzamide

“…For related literature, see: Capdeville et al (2002); Ho et al (2002); Igawa et al (1999); Jackson et al (1994); Makino et al (2001Makino et al ( , 2003; Manley et al (2002); Zhichkin et al (2007).…”

“…The benzanilide core is present in compounds with such a wide range of biological activities that it has been called a privileged structure. Benzanilides serve as intermediates towards benzothiadiazin-4-ones (Makino et al, 2003), quinazoline-2,4-diones (Makino et al, 2001) and benzodiazepine-2,5-diones (Ho et al, 2002) and δ kinase inhibitors 2,3disubstituted 3H-quinazoline-4-ones (Zhichkin et al, 2007). Benzanilides have established their efficacy as centroid elements of ligands that bind to a wide variety of receptor types.…”

N-(2,4-Dichlorophenyl)-2-nitrobenzamide

“…For related literature, see: Igawa et al (1999); Jackson et al (1994); Makino et al (2001Makino et al ( , 2003; Manley et al (2002); Zhichkin et al (2007); Capdeville et al (2002); Ho et al (2002).…”

“…The benzanilide core is present in compounds with such a wide range of biological activities that it has been called a privileged structural motif. Benzanilides serve as intermediates towards benzothiadiazin-4-ones (Makino et al, 2003), quinazoline-2,4-diones (Makino et al, 2001) and benzodiazepine-2,5-diones (Ho et al, 2002). 2,3-disubstituted 3Hquinazoline-4-ones act as 110δ kinase inhibitors (Zhichkin et al, 2007).…”