Synthesis of 1,3‐ and 1,2‐Diphosphatidylglycerol

Ahmad, M. S.; Krishna, U. Murali; Ali, Shoukath M.; Choudhury, Sreeti; Ahmad, Imran

doi:10.1007/s11745-007-3020-1

Cited by 4 publications

(3 citation statements)

References 15 publications

(21 reference statements)

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“…Glycerophospholipids are the major membrane lipids with broad bioactivities and several synthetic routes were reported in the literature for its nonpolar derivatives (Ahmad et al 2007;Leßig and Fuchs 2010). However, synthesis of more polar GPL was limited in the literature.…”

Section: Resultsmentioning

confidence: 99%

A Simple and Efficient Method for Synthesis of sn‐Glycero‐Phosphoethanolamine

Gowda

Fuda

Yamamoto

et al. 2020

Lipids

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An efficient three-step strategy for the convenient synthesis of Sn-glycero-3phosphoethanolamine (GroPEtn) from a commercially available 1,2-Dipalmitoyl-sn-glycero-3phosphoethanolamine (DPPE) is reported. Direct hydrolysis of DPPE produce a complex inseparable mixture, hence a protection and deprotection strategy is employed to prepare GroPEtn. The primary amine of DPPE is protected with a highly stable acid-labile trityl group, followed by strong base hydrolysis of N-trityl-DPPE gives N-trityl-GroPEtn. Further a mild, rapid, and efficient deprotection method is established using trifluoroacetic acid to remove Ntrityl moiety, affords GroPEtn as a single product. This is the first semisynthetic approach and efficient method to produce GroPEtn with a total yield of 66% in three steps. GroPEtn did not show any cytotoxicity against human kidney (HK-2) cells and reporter gene assay for activation of Keap1-Nrf2 mediated antioxidant defense mechanism showed no significant effects.

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Section: Resultsmentioning

confidence: 99%

A Simple and Efficient Method for Synthesis of sn‐Glycero‐Phosphoethanolamine

Gowda

Fuda

Yamamoto

et al. 2020

Lipids

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“…Citons par exemple les volumineux kystes prostatiques (kystes müllériens le plus souvent) qui vont comprimer les canaux éjaculateurs, les sténoses scléroatro-phiques postinfectieuses ou postchirurgicales des voies séminales [34,35] ou encore les lithiases des canaux éjaculateurs, fréquemment associées à une hémospermie [36,37].…”

Section: Hypospermies Secondaires à Un Défaut Anatomique Et/ou De Fonunclassified

“….) évoquant un hypogonadisme [42] ; une hémospermie, pouvant évoquer une lithiase des canaux éjaculateurs [37]. La recherche d'un éventuel trouble mictionnel associé doit être également renseignée.…”

Section: Eléments De L'interrogatoireunclassified

Pourquoi et comment réaliser un bilan d’hypospermie ?

Robin¹,

Marcelli²,

Mitchell³

et al. 2008

Gynécologie Obstétrique & Fertilité

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The physicochemical properties of cardiolipin bilayers and cardiolipin-containing lipid membranes

Lewis

McElhaney

2009

Biochimica et Biophysica Acta (BBA) - Biomembranes

232

187

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In this review article, we summarize the current state of biophysical knowledge concerning the phase behavior and organization of cardiolipin (CL) and CL-containing phospholipid bilayer model membranes. We first briefly consider the occurrence and distribution of CL in biological membranes and its probable biological functions therein. We next consider the unique chemical structure of the CL molecule and how this structure may determine its distinctive physical properties. We then consider in some detail the thermotropic phase behavior and organization of CL and CL-containing lipid model membranes as revealed by a variety of biophysical techniques. We also attempt to relate the chemical properties of CL to its function in the biological membranes in which it occurs. Finally, we point out the requirement for additional biophysical studies of both lipid model and biological membranes in order to increase our currently limited understanding of the relationship between CL structure and physical properties and CL function in biological membranes.

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Synthesis of 1,3‐ and 1,2‐Diphosphatidylglycerol

Cited by 4 publications

References 15 publications

A Simple and Efficient Method for Synthesis of sn‐Glycero‐Phosphoethanolamine

A Simple and Efficient Method for Synthesis of sn‐Glycero‐Phosphoethanolamine

Pourquoi et comment réaliser un bilan d’hypospermie ?

The physicochemical properties of cardiolipin bilayers and cardiolipin-containing lipid membranes

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