Synthesis, molecular docking study and antitumor activity of novel 2-phenylindole derivatives

El-Nakkady, Sally S.; Hanna, Mona M.; Roaiah, Hanaa M. F.; Ghannam, Iman A.Y.

doi:10.1016/j.ejmech.2011.11.007

Cited by 45 publications

(17 citation statements)

References 23 publications

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“…A series of 2-arylquinoline-4-carboxalic acid hydrazidhydrazones were exhibited in vitro antimicrobial activity against S. aureus, E. coli and C. albicans. Out of these compounds 6-chloro-2-(4-methoxyphenyl) quinoline-4-carboxylic acid (4-nitrobenzylidene)-hydrazide [34] was found to be most potent (Metwally et al, 2006). Some p-substituted benzoic acid ((5-nitro-thiophen-2-yl)-methylene)-hydrazides were showed antimicrobial activity against standard and MDR strains of S. aureus.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Pharmacologically potentials of hydrazonone containing compounds: a promising scaffold

Asif

2014

International Journal of Advanced Chemistry

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Section: Antimicrobial Activitymentioning

confidence: 99%

Pharmacologically potentials of hydrazonone containing compounds: a promising scaffold

Asif

2014

International Journal of Advanced Chemistry

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“…Several reports suggest that molecules with indole nucleus have promising antiproliferative activity by inhibiting tubulin polymerization [44]. We obtained the structural information of tubulin in complex with compound CN2 from protein Data Bank (PDB ID: 1SA0) [45].…”

Section: Molecular Dockingmentioning

confidence: 99%

Synthesis, Characterization, Molecular Docking, Cytotoxic and Antioxidant Activities of Di(indolyl)thiazolylpyrazoles

Nagarjuna¹,

Madhusekhar²,

Trinath³

et al. 2017

Med chem

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Some new di(indolyl)thiazolylpyrazoles were prepared from the synthetic intermediate E-1,3-di(1H-indol-3-yl) prop-2-en-1-one under ultrasonication and studied their cytotoxic and antioxidant activities. All the compounds were screened for in vitro cytotoxic activity on three cancer cell lines. The compound 7e exhibited appreciable anticancer activity on NCI-H1299, HCT-166 p53 and PC-3 cancer cell lines. The binding conformation of the target molecules was predicted by docking methodology to explain the biological activities. In fact, the docking studies indicated that could be used as possible leads for therapies against cancers. Amongst all the tested compounds dimethoxy substituted di(indolyl)thiazolylpyrazole (7i) displayed significant radical scavenging activity.

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“…The hydrazine derivatives 5a-c were obtained by the reaction of 1H-indole-3-carboxaldehyde derivative 4 with different substituted hydrazines [20] namely, hydrazine hydrate, phenyl hydrazine and 2-hydrazinyl-1,3-benzothiazole (Scheme 1). The molecular structure of the synthesis compounds were established based on analytical and spectral data.…”

Section: Chemistrymentioning

confidence: 99%

Synthesis, Reactions and Antimicrobial Activity of Some New 3-Substituted Indole Derivatives

Salman¹,

Mahmoud²,

Abdel‐Aziem³

et al. 2015

IJOC

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Reaction of indole-3-carboxaldehydes 4 with hydrazine derivatives and different substituted acid hydrazides afforded the corresponding hydrazine derivatives 5a-c and acid hydrazide derivatives 7-11 respectively. Condensation of indole-3-carboxaldehydes 4 with phenacyl bromide and thiourea gives 1,3-thiazol-2-amine derivative 18. On the other hand, reaction 4 with 3-acetylchromene-2-one afforded chalcone derivative 19. Compound 4 undergoing Knoevenagel condensation with cyanoacetamide, ethyl cyanoacetate, benzimidazol-2-ylacetonitrile, rhodanine-3-acetic acid, 2,3-dihydropyrimidin-4-one derivative and 2,4-dihydropyrazol-3-one afforded the compounds 20a,b, 22, 23, 27 and 28 respectively. The structure of the newly synthesized compounds has been confirmed by elemental analysis and spectra data. The antimicrobial activities of the some newly synthesized compounds were measured and showed that most of them have high activities.

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Synthesis, molecular docking study and antitumor activity of novel 2-phenylindole derivatives

Cited by 45 publications

References 23 publications

Pharmacologically potentials of hydrazonone containing compounds: a promising scaffold

Pharmacologically potentials of hydrazonone containing compounds: a promising scaffold

Synthesis, Characterization, Molecular Docking, Cytotoxic and Antioxidant Activities of Di(indolyl)thiazolylpyrazoles

Synthesis, Reactions and Antimicrobial Activity of Some New 3-Substituted Indole Derivatives

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