Synthesis, mechanical properties, biocompatibility, and biodegradation of polyurethane networks from lysine polyisocyanates

Guelcher, Scott A.; Srinivasan, Ashok; Dumas, Jerald E.; Didier, Jonathan E.; McBride, Sean; Hollinger, Jeffrey O.

doi:10.1016/j.biomaterials.2007.12.046

Cited by 156 publications

(106 citation statements)

References 35 publications

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“…The biocompatibility of lactide-caprolactone structures obtained by reaction with LTI has been confirmed by other studies on the characterization and synthesis of co-polyester-urethane networks for medical purpose and application [11][12][13]. In order to have an optimal performance of these materials, it's very important that also their degradation products are nontoxic and biocompatible.…”

mentioning

confidence: 64%

Effect of Ethyl Ester L-Lysine Triisocyanate addition to produce reactive PLA/PCL bio-polyester blends for biomedical applications

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Giamporcaro

et al. 2017

Journal of the Mechanical Behavior of Biomedical Materials

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mentioning

confidence: 64%

Effect of Ethyl Ester L-Lysine Triisocyanate addition to produce reactive PLA/PCL bio-polyester blends for biomedical applications

Visco

Nocita

Giamporcaro

et al. 2017

Journal of the Mechanical Behavior of Biomedical Materials

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“…The densities of polyurethanes and their composites were similar (about 1.07 g/cm 3 , Table 3). Cross-linked polyurethanes and their composites absorbed very small amount of vegetable oil after 24 hours of incubation -their weight changed insignificantly (Table 3) in sorption tests.…”

Section: T a B L E 2 Thermal Properties Of Polyurethanes And Their Cmentioning

confidence: 79%

“…Cross-linked polyurethanes (PUR) are mainly obtained in the reaction of isocyanates with polyols and low-molecular compounds, of which at least one type of reagent is multifunctional [1][2][3]. They can be also synthesized via reaction with using unsaturated compounds [4,5].…”

Section: Podatność Na Degradację Kompozytów Usieciowanych Poliuretanómentioning

confidence: 99%

“…Postęp rozkładu kompozytów oceniano na podstawie zmiany masy, powierzchni i właściwości termicznych próbek. Zarówno zwiększenie zawartości poli([R,S]-3-hydroksymaślanu) w segmencie giętkim poliuretanów, jak i zmieszanie ich z chitozanem spowodowało wzrost podatności usieciowanych poliuretanów na degradację w obu rodzajach roztworów.Słowa kluczowe: usieciowane poliuretany, chitozan, kompozyty, podatność poliuretanów na degradację.Cross-linked polyurethanes (PUR) are mainly obtained in the reaction of isocyanates with polyols and low-molecular compounds, of which at least one type of reagent is multifunctional [1][2][3]. They can be also synthesized via reaction with using unsaturated compounds [4,5].…”

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Degradability of cross-linked polyurethanes/chitosan composites

et al. 2017

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Polyurethanes with synthetic poly([R,S]-3-hydroxybutyrate) in the soft segment and with polycaprolactone triol as cross-linker were blended with chitosan and degraded in hydrolytic and oxidative solutions. Progress of the degradation of the samples was evaluated by changes in their weight, surface topography and thermal properties. Increasing the poly([R,S]-3-hydroxybutyrate) content in soft segment as well as blending with chitosan resulted in an increase in degradability of cross-linked polyurethanes in both solutions.Keywords: cross-linked polyurethanes, chitosan, composites, polyurethane degradability. Podatność na degradację kompozytów usieciowanych poliuretanów z chitozanemStreszczenie: Poliuretany zawierające syntetyczny poli([R,S]-3-hydroksymaślan) w segmencie gięt-kim oraz polikaprolaktonotriol jako związek sieciujący zmieszano z chitozanem i poddano degradacji w roztworach hydrolitycznym i utleniającym. Postęp rozkładu kompozytów oceniano na podstawie zmiany masy, powierzchni i właściwości termicznych próbek. Zarówno zwiększenie zawartości poli([R,S]-3-hydroksymaślanu) w segmencie giętkim poliuretanów, jak i zmieszanie ich z chitozanem spowodowało wzrost podatności usieciowanych poliuretanów na degradację w obu rodzajach roztworów.Słowa kluczowe: usieciowane poliuretany, chitozan, kompozyty, podatność poliuretanów na degradację.Cross-linked polyurethanes (PUR) are mainly obtained in the reaction of isocyanates with polyols and low-molecular compounds, of which at least one type of reagent is multifunctional [1][2][3]. They can be also synthesized via reaction with using unsaturated compounds [4,5]. Cross-linked polyurethanes are not dissolved in the solvent but swelled. With an increase in the degree of cross-linking their elasticity decreases but stiffness increases. They are mainly used as coatings, membrane and shape memory materials [6].Cross-linked polyurethanes are generally less susceptible to degradation than linear polyurethanes. The presence of cross-linkages between chains of polyurethane significantly hinders the migration of water with enzymes, free radicals, and other degradative molecules into the polymer network [6].But, in some cases, the presence of a triol cross-linker in polyurethane structure leads to a polymer with no phase separation. Disordering of the polymer network and reduced mobility of the chains (as a result of chemical cross-linking) allow the ester/ether groups to be exposed to water. In this case cross-linked polyurethanes can be susceptible to degradation [7].The process of degradation of cross-linked polyurethanes can be accelerated by introducing the groups susceptible to degradation (such as ester groups) into their structure or by blending with degradable polymers. Natural polymers or their synthetic analogues (such as polyhydroxybutyrate, polycaprolactone, and chitosan) can be used as part of polyurethane network or as composite fillers.

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“…Nowadays, the needs for bone repair surgery focus more and more on sophisticated regenerative scaffolds, such as injectable calcium phosphate based material for minimally invasive surgical techniques [1][2][3][4][5][6][7][8][9][10]. In that context, two original devices made of biphasic calcium phosphate (BCP) granules suspended into polysaccharide-based media were designed in our laboratory about ten years ago [11][12][13][14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

The in vivo degradation of a ruthenium labelled polysaccharide-based hydrogel for bone tissue engineering

et al. 2009

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a b s t r a c tIn this paper we report a new method that permitted for the first time to selectively track a polysaccharide-based hydrogel on bone tissue explants, several weeks after its implantation. The hydrogel, which was developed for bone healing and tissue engineering, was labelled with a ruthenium complex and implanted into rabbit bone defects in order to investigate its in vivo degradation. 1, 2, 3 and 8 weeks after surgery, the bone explants were analyzed by synchrotron X-ray microfluorescence, infrared mapping spectroscopy, scanning electron microscopy, and optical microscopy after histological coloration. The results showed that the labelled polysaccharide-based hydrogel was likely to undergo phagocytosis that seemed to occur from the edge to the center of the implantation site up to at least the 8th week.

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Synthesis, mechanical properties, biocompatibility, and biodegradation of polyurethane networks from lysine polyisocyanates

Cited by 156 publications

References 35 publications

Effect of Ethyl Ester L-Lysine Triisocyanate addition to produce reactive PLA/PCL bio-polyester blends for biomedical applications

Effect of Ethyl Ester L-Lysine Triisocyanate addition to produce reactive PLA/PCL bio-polyester blends for biomedical applications

Degradability of cross-linked polyurethanes/chitosan composites

The in vivo degradation of a ruthenium labelled polysaccharide-based hydrogel for bone tissue engineering

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