Synthesis, herbicidal activity study and molecular docking of novel pyrimidine thiourea

Recent trends in chemistry, structure, and various applications of 1-acyl-3-substituted thioureas: a detailed review

“…Li et al 4 synthesized a new series of thioureas containing substituted pyrimidines 116a–j ( Scheme 51 ). The newly prepared compounds were tested for herbicidal activity, and the preliminary results indicated some derivatives had good activity against Amaranthus retroflexus , and Digitaria adscendens , particularly compound 116d and 116f displayed inhibitory potential on D. adscendens .…”

“…2,3 Extensive studies showed they play a promising role in the fields of molecular recognition, materials science, agriculture, pharmaceuticals, and biological activities. Various articles have demonstrated the important biological activities of thioureas such as, herbicidal, 4 insecticidal, 5 antimicrobial, 6 antitumor, 7 antiviral, 8 antiparasitic, 9 antidiabetic, 10 fungicidal, pesticidal, 11,12 and urease inhibitory activities. 13,14 The 1 H -imidazol thiourea derivatives emerged as promising anti-HIV agents.…”

Novel Pyrimidine Derivatives Bearing a 1,3,4-Thiadiazole Skeleton: Design, Synthesis, and Antifungal Activity

“…Meanwhile, in the agricultural field, pyrimidine derivatives also have good biological activities such as antiviral ( Wu, et al, 2015 ; Zan et al, 2020 ), insecticidal ( Liu, et al, 2017 ; Wu, et al, 2019 ; Chen, et al, 2021 ; Liu, et al, 2021 ; Sun, et al, 2021 ), fungicidal ( Guan et al, 2017 ; Yan et al, 2020 ; Yang, et al, 2020 ), bactericidal ( Li et al, 2020 ), herbicidal ( Chen et al, 2019 ; Li et al, 2020 ), and anticancer ( Guo et al, 2020 ) properties. In the last few decades, some pyrimidine derivatives have been commercialized as pesticides for controlling plant diseases and insect pests.…”

Synthesis and Antifungal Activity of Pyrimidine Derivatives Containing an Amide Moiety

“…Due to the excellent features of low toxicity, the fact that it is easily synthetized and derived, and considering pyrimidine as a parent compound, the development of promising agrochemical candidates will soon become a reality. Meanwhile, amine, a key moiety in heterocyclic chemistry, play a leading role in pesticide chemistry due to their potent bioactivities including antifungal ( Cheng et al, 2020 ; Chen et al, 2021a ), antibacterial ( Chen et al, 2021a ), antiviral ( Tang et al, 2020 ), herbicidal ( Sun et al, 2020 ), and insecticidal ( Chen et al, 2021b ; Li et al, 2021b ) activities. In our previous work, we reported a series of novel pyrimidine derivatives containing an amine moiety ( Figure 1 ) and found that the target compounds revealed certain antifungal, insecticidal, and antiviral activities ( Wu et al, 2016a : Wu et al, 2020 ).…”