“…The biological importance of these Schiff's base chelates of thiosemicabazides involved the researchers greater than before to develop fresh ligands as antibacterial [16], antimicrobial [17][18][19], antifungal [20,21], antiparasitic [22], antitumor [23], anticancer [24][25][26], antioxidant [27,28], anti-inflammatory [29], anti-HIV [30], antiproliferative [31], antileishmanial activities [32] and antiviral [33]. Tetradentate thiosemicabazone with strong DNA-binding ability was isolated after the condensation of pyruvaldehyde with 4-(aryl)-thiosemicarbazones [34].…”