Synthesis, crystallographic studies, electrochemical and in vitro cytotoxicity properties of two Mn(II) and U(IV) complexes containing dipicolinic acid and 4-dimethylaminopyridine
“…The investigations indicated that ligands do not have remarkable electrochemical reactivity. Therefore, redox couples are related to only the metal centers in complexes 27 , 28 . Figure 4 Cyclic voltammogram of complexes c = 4 × 10 –3 mol/dm 3 in H 2 O medium, KCl (0.1 M) at GCE, scan rate 50 V/s.…”
Section: Resultsmentioning
confidence: 99%
“…In our study, three new Tl(III) complexes with pyridine dicarboxylic acid derivatives were reported. Many studies have proved that the pyridine dicarboxylates family as a ligand can be suitable options to design diversity of metal complexes 28 – 30 . Here, electrochemical studies confirmed that these ligands, despite having no electrochemical activity, can affect the electrochemical activity of the complexes.…”
Three novel Tl(III) complexes (C1), (C2) and (C3) were synthesized using the one-pot reactions of pyridine dicarboxylic acid derivatives, 2-aminobenzimidazole and/or 4-aminopyridine, and also thallium(III) nitrate trihydrate metal salt. The structure of all three complexes was determined by the single-crystal X-ray diffraction. C1 and C2 were realized to be isostructural with disordered square anti-prismatic geometry and for C3 arrangement of the distorted tricapped triangular prism was proposed. Cyclic voltammetry measurements on the complexes exhibited that formal potential values are more positive for C1 (E0ˊ 0.109 V) and C3 (E0ˊ 0.244 V) compared to C2 (E0ˊ –0.051 V), versus Ag/AgCl under argon. Moreover, cytotoxicity of the compounds was evaluated in vitro against two cancer cell lines including a human melanoma (A375), a human colon adenocarcinoma (HT29), and also one normal cell human foreskin fibroblast (HFF). The selective and potent cytotoxicity effect was exhibited by C1 and C3 on cancer cell lines. The apoptosis through a caspase-dependent mitochondrion pathway was confirmed by ROS production, MMP reduction, p53 activation, Bax up-regulation, and Bcl-2 down-regulation, cytochrome c release, procaspase-9, and 3 expression, for A375 cells treated to C1 and C3. According to similar cellular uptake of the complexes in A375 cell line, the generation of ROS was considered as an effective agent to justify the inhibition effect C1 and C3 on mentioned cells. Furthermore, arresting the cell cycle in the G2-M phase and inducing apoptosis were indicated by these two complexes.
“…The investigations indicated that ligands do not have remarkable electrochemical reactivity. Therefore, redox couples are related to only the metal centers in complexes 27 , 28 . Figure 4 Cyclic voltammogram of complexes c = 4 × 10 –3 mol/dm 3 in H 2 O medium, KCl (0.1 M) at GCE, scan rate 50 V/s.…”
Section: Resultsmentioning
confidence: 99%
“…In our study, three new Tl(III) complexes with pyridine dicarboxylic acid derivatives were reported. Many studies have proved that the pyridine dicarboxylates family as a ligand can be suitable options to design diversity of metal complexes 28 – 30 . Here, electrochemical studies confirmed that these ligands, despite having no electrochemical activity, can affect the electrochemical activity of the complexes.…”
Three novel Tl(III) complexes (C1), (C2) and (C3) were synthesized using the one-pot reactions of pyridine dicarboxylic acid derivatives, 2-aminobenzimidazole and/or 4-aminopyridine, and also thallium(III) nitrate trihydrate metal salt. The structure of all three complexes was determined by the single-crystal X-ray diffraction. C1 and C2 were realized to be isostructural with disordered square anti-prismatic geometry and for C3 arrangement of the distorted tricapped triangular prism was proposed. Cyclic voltammetry measurements on the complexes exhibited that formal potential values are more positive for C1 (E0ˊ 0.109 V) and C3 (E0ˊ 0.244 V) compared to C2 (E0ˊ –0.051 V), versus Ag/AgCl under argon. Moreover, cytotoxicity of the compounds was evaluated in vitro against two cancer cell lines including a human melanoma (A375), a human colon adenocarcinoma (HT29), and also one normal cell human foreskin fibroblast (HFF). The selective and potent cytotoxicity effect was exhibited by C1 and C3 on cancer cell lines. The apoptosis through a caspase-dependent mitochondrion pathway was confirmed by ROS production, MMP reduction, p53 activation, Bax up-regulation, and Bcl-2 down-regulation, cytochrome c release, procaspase-9, and 3 expression, for A375 cells treated to C1 and C3. According to similar cellular uptake of the complexes in A375 cell line, the generation of ROS was considered as an effective agent to justify the inhibition effect C1 and C3 on mentioned cells. Furthermore, arresting the cell cycle in the G2-M phase and inducing apoptosis were indicated by these two complexes.
“…Strong cytotoxicity by both C1 and C2 toward MCF7 cell line is a prominent property that merits these complexes to further studies in the field of anticancer properties. Such features may be arising to the effectiveness of these compounds on disproportionate H 2 O 2 and generate active intermediates [47,48].…”
Three oxorhenium(V) complexes [ReOLCl2(PPh3)] (C1–C3) were synthesized in the reaction of 2,3‐pyridinedicarboxylic acid (HL1), 2,5‐pyridinedicarboxylic acid (HL2), and 2,6‐pyridinedicarboxylic acid (HL3) with [ReOCl3(PPh3)2]. Chemical structures of synthesized compounds were confirmed using standard analytical techniques. The most stable geometry of complexes was proposed using density functional theory calculations. The antiproliferative activity of the synthesized complexes was evaluated in a panel of human tumor cell lines (A549, PANC‐1, OVCAR‐3, and MDA‐MB‐231) and in one nontumor cell line (MRC‐5), in comparison with the activity of cisplatin as a reference drug. The complex C3 exhibited the highest antiproliferative potential in PANC‐1 cells, with IC50 48.73 ± 0.31 μM. Our previous research of oxorhenium(V) complexes suggested the involvement of drug‐efflux transporter P‐glycoprotein (Pgp) in the detoxification of rhenium complexes in pancreatic adenocarcinoma cells. In the present study, the effect of verapamil hydrochloride, the specific pharmacological blocker of Pgp, was tested in combination with novel rhenium complexes C1–C3 or cisplatin (CDDP), in PANC‐1 cells. The verapamil enhanced the antiproliferative activity of complex C3, indicating again the role of Pgp in detoxification of oxorhenium(V) complexes in highly invasive and resistant PANC‐1 cells.
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