Synthesis, characterization, crystallographic structure, theoretical studies, and in vitro cytotoxicity assessment of two Gd(III) and Ce(IV) complexes containing pyridine-2,6-dicarboxylate

Zohrevandi, Mina; Abdolmaleki, Sara; Ghadermazi, Mohammad; Gholiee, Yasin; Aliabadi, Alireza; Motieiyan, Elham; Hakimi, Mohammad; Marabello, Domenica

doi:10.1016/j.poly.2021.115561

Cited by 8 publications

(1 citation statement)

References 53 publications

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“…Thus, the complex of 8-hydroxyquinolone derivative [CeL 4 ] is effective against human ovarian (SK-OV-3), liver (BEL-744), and lung (NCl-H460) cancer cells, with good selectivity compared to a normal liver cell line (HL-7702) [ 55 ]. The Ce(IV) complex of 3-MBTMPD imine derivative [CeL(NO 3 ) 2 (H 2 O) 2 ] possesses significant cytotoxicity in cervical (HeLa) and breast (MCF-7) cancer cells [ 56 ], while the Ce(IV)-bearing dicarboxylate [CeL 3 ] 2− shows activity against breast cancer (MCF-7), colon adenocarcinoma (HT-29) and lymphocyte (HT-60) cells [ 57 ].…”

Section: Introductionmentioning

confidence: 99%

Novel Cerium(IV) Coordination Compounds of Monensin and Salinomycin

et al. 2023

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The largely uncharted complexation chemistry of the veterinary polyether ionophores, monensic and salinomycinic acids (HL) with metal ions of type M4+ and the known antiproliferative potential of antibiotics has provoked our interest in exploring the coordination processes between MonH/SalH and ions of Ce4+. (1) Methods: Novel monensinate and salinomycinate cerium(IV)-based complexes were synthesized and structurally characterized by elemental analysis, a plethora of physicochemical methods, density functional theory, molecular dynamics, and biological assays. (2) Results: The formation of coordination species of a general composition [CeL2(OH)2] and [CeL(NO3)2(OH)], depending on reaction conditions, was proven both experimentally and theoretically. The metal(IV) complexes [CeL(NO3)2(OH)] possess promising cytotoxic activity against the human tumor uterine cervix (HeLa) cell line, being highly selective (non-tumor embryo Lep-3 vs. HeLa) compared to cisplatin, oxaliplatin, and epirubicin.

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Section: Introductionmentioning

confidence: 99%

Novel Cerium(IV) Coordination Compounds of Monensin and Salinomycin

et al. 2023

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New α‐Imido‐β‐diarylphosphorylpropanoates and their Complexes with Gadolinium(III)

et al. 2022

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A practical route is described for the preparation of α‐imido‐β‐diarylphosphorylpropanoates based on the phosphine‐catalyzed α‐umpolung/β‐Michael addition reaction. One of the products has been tested for coordination the Gd3+ cation using NMR relaxation method in solution and by IR spectroscopy to solids. The exact structures of two isomers of the obtained complex have been determined by single crystal analysis. The structures of all isomers were investigated by quantum‐chemical calculations in solution. Quantum‐chemical calculations results show the presence of stereoselective effect in solution: the trans‐isomer with two ligands having different chirality is energetically more favorable. The cis‐isomer with ligands of different chirality is the least advantageous in terms of energy and therefore presents in solution in small amounts. The cis‐ and trans‐isomers with two ligands of the same chirality are very close in energy but are somewhat inferior to the most stable isomer.

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Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review

Abdolmaleki,

Aliabadi,

Khaksar

2024

J Cancer Res Clin Oncol

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Copper is a necessary micronutrient for maintaining the well-being of the human body. The biological activity of organic ligands, especially their anticancer activity, is often enhanced when they coordinate with copper(I) and (II) ions. Copper and its compounds are capable of inducing tumor cell death through various mechanisms of action, including activation of apoptosis signaling pathways by reactive oxygen species (ROS), inhibition of angiogenesis, induction of cuproptosis, and paraptosis. Some of the copper complexes are currently being evaluated in clinical trials for their ability to map tumor hypoxia in various cancers, including locally advanced rectal cancer and bulky tumors. Several studies have shown that copper nanoparticles can be used as effective agents in chemodynamic therapy, phototherapy, hyperthermia, and immunotherapy. Despite the promising anticancer activity of copper-based compounds, their use in clinical trials is subject to certain limitations. Elevated copper concentrations may promote tumor growth, angiogenesis, and metastasis by affecting cellular processes.

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Synthesis, characterization, crystallographic structure, theoretical studies, and in vitro cytotoxicity assessment of two Gd(III) and Ce(IV) complexes containing pyridine-2,6-dicarboxylate

Cited by 8 publications

References 53 publications

Novel Cerium(IV) Coordination Compounds of Monensin and Salinomycin

Novel Cerium(IV) Coordination Compounds of Monensin and Salinomycin

New α‐Imido‐β‐diarylphosphorylpropanoates and their Complexes with Gadolinium(III)

Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review

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