Synthesis, crystal structures, antimicrobial properties and enzyme inhibition studies of zinc(II) complexes of thiones

Malik, Muhammad Riaz; Vasylyeva, Vera; Merz, Klaus; Metzler‐Nolte, Nils; Saleem, Muhammad; Ali, Saqib; Isab, Anvarhusein A.; Munawar, Khurram Shahzad; Ahmad, Saeed

doi:10.1016/j.ica.2011.06.017

Cited by 59 publications

(22 citation statements)

References 38 publications

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“…The downfield shift is related to an increase in p electron density in the C-N bond upon coordination to Cadmium. In the 13 C NMR spectra of both complexes, the carbon atom of the [C=S unit is shifted upfield by about 1.5 ppm as compared to the free ligand's resonances in accordance with the data observed for other complexes of cadmium(II) [14,26,31,32]. Table 3.…”

Section: Ir and Nmr Studiessupporting

confidence: 84%

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Synthesis and Crystal Structures of Cadmium Iodide Complexes of N,N′-Diethylthiourea and 1,3-Diazinane-2-thione

Ahmad

Amir²,

Naz

et al. 2012

J Chem Crystallogr

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Two cadmium(II) iodide complexes, [Cd(Detu) 2 I 2 ] (1) and [Cd(Diaz) 2 I 2 ] (2) (Detu = N,N 0 -diethylthiourea; Diaz = 1,3-diazinane-2-thione) have been prepared and their structures been determined by X-ray crystallography. The crystal structures show that both complexes are mononuclear with the cadmium atom coordinated to two iodide ions and two thione ligands adopting a distorted tetrahedral geometry. Whereas, 2 exists as discrete monomeric species, the structure of 1 consists of three crystallographically independent molecules. The complexes were also characterized by IR and NMR ( 1 H and 13 C) spectroscopy.

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Section: Ir and Nmr Studiessupporting

confidence: 84%

“…The selected IR bands of the ligands and their cadmium(II) complexes are given in Table 2. In IR spectra of these complexes, the shifts in the m(C=S), m(N-H) and m(C-N) bands are indicative of coordination of the ligands to the metal center in the solid state [14,26,31,32].…”

Section: Ir and Nmr Studiesmentioning

confidence: 99%

Synthesis and Crystal Structures of Cadmium Iodide Complexes of N,N′-Diethylthiourea and 1,3-Diazinane-2-thione

Ahmad

Amir²,

Naz

et al. 2012

J Chem Crystallogr

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“…Their nonequivalency may be associated with the formation of hydrogen bonds to different chlorine atoms (Cl1 and Cl2), which behave differently in the solid state (vide infra). In the 13 C NMR spectrum of 1, the C=S resonance of dmtu was shifted upfield with respect to its position in free state (171.64, 171.74 vs. 182.7 ppm) in accordance with the data observed for other complexes [34,36,37]. The doublet appearance of thiocarbonyl resonance indicates that the two dmtu molecules are bearing somewhat different environment.…”

Section: Resultssupporting

confidence: 82%

“…Antimicrobial activities of the title complex were estimated by minimum inhibitory concentration (MIC, lg/cm 3 ) as described earlier [36]. Standard culture media of bacteria, E. coli (ATCC 13706) and P. aeruginosa (MTCC 424), molds, A. niger (MTCC 1349) and P. citrinum (MTCC 5215) and yeasts, C. albicans (MTCC 183) and S. cerevisiae (MTCC 463) were obtained from Qingdao Yijia Huuyi Co. China.…”

Section: Antimicrobial Studiesmentioning

confidence: 99%

Crystal structure and antimicrobial activity of a transplatin adduct of N,N′-dimethylthiourea, trans-[Pt(NH3)2(dmtu)2]Cl2

et al. 2016

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The crystal structure of a transplatin-derived complex, trans-[Pt(NH 3 ) 2 (dmtu) 2 ]Cl 2 (dmtu = N,N ' -dimethylthiourea) was determined by X-ray crystallography and its antimicrobial activities were evaluated by minimum inhibitory concentration. The structure consists of trans-[Pt(NH 3 ) 2 (dmtu) 2 ] 2? cation and two chloride ions. In trans-[Pt(NH 3 ) 2 (dmtu) 2 ] 2? , the geometry at platinum is nearly regular square planar with the average cis and trans angles of 90 and 178.6°, respectively. The 1 H and 13 C NMR spectral data indicated the coordination of both ligands to platinum(II). The results of antimicrobial studies showed that the complex exhibited significant activity against gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), while relatively poor activities were observed against molds (Aspergillus niger, Penicillium citrinum) and yeasts (Candida albicans, Saccharomyces cerevisiae). Graphical abstract

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“…The assay of inhibition of ALPs was done spectrophotometrically as described earlier [12]. Working substrate was prepared by mixing four parts of diethanolamine (pH = 9.8, 2 mol/dm ALP activity was assayed with 25 mM stock solutions of OMZ, HQL and the synthesized complexes.…”

Section: Assay Of Inhibitory Effects Of Metal Complexes On Alpsmentioning

confidence: 99%

Synthesis, characterization and pharmacological evaluation of mixed ligand-metal complexes containing omeprazole and 8-hydroxyquinoline

Ahmad¹,

Khan²,

Munawar³

et al. 2017

Trop. J. Pharm Res

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Synthesis, crystal structures, antimicrobial properties and enzyme inhibition studies of zinc(II) complexes of thiones

Cited by 59 publications

References 38 publications

Synthesis and Crystal Structures of Cadmium Iodide Complexes of N,N′-Diethylthiourea and 1,3-Diazinane-2-thione

Synthesis and Crystal Structures of Cadmium Iodide Complexes of N,N′-Diethylthiourea and 1,3-Diazinane-2-thione

Crystal structure and antimicrobial activity of a transplatin adduct of N,N′-dimethylthiourea, trans-[Pt(NH3)2(dmtu)2]Cl2

Synthesis, characterization and pharmacological evaluation of mixed ligand-metal complexes containing omeprazole and 8-hydroxyquinoline

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