Synthesis, characterization and pharmacological evaluation of mixed ligand-metal complexes containing omeprazole and 8-hydroxyquinoline

Ahmad, Waqar; Khan, Shakeel Ahmad; Munawar, Khurram Shahzad; Khalid, Asma; Kawanl, Sadia

doi:10.4314/tjpr.v16i5.23

Cited by 27 publications

(14 citation statements)

References 20 publications

(16 reference statements)

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“…First, plant seeds were washed to remove dust; after that, they were shade dried at a temperature of 25-30 °C [12]. With the help of a commercial blender (FTA-788, West point, Germany), seeds were pulverized and then sieved (150 mesh sieve (0.065 mm)) [13]. The resultant seed powder material was stored in an airtight container.…”

Section: Sample and Extract Preparationmentioning

confidence: 99%

Antioxidant activity and hepatoprotective effect of <i>Cichorium intybus</i> (Kasni) seed extract against carbon tetrachloride-induced liver toxicity in rats

Khalid¹,

Shahid²,

Khan³

et al. 2018

Trop. J. Pharm Res

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Purpose: To assess the antioxidant and hepatoprotective activity of the aqueous-methanol extract of Cichorium intybus seeds (C. intybus) against carbon tetrachloride (CCl4)-induced liver toxicity in albino Wistar rats. Method: The seed extract of C. intybus was prepared in aqueous methanol (20:80) via Soxhlet solvent extraction process. CCl4 (0.8 mL/kg) was administered to induce hepatic damage in Wistar rats. The seed extract (100, 250 and 500 mg/kg doses) and a 25 mg/kg dose of silymarin (as standard drug) were administered orally to separate groups of albino Wistar rats for 14 days. Blood samples from the rats were analyzed for biochemical markers for hepatic injury. The tissue samples of the rats were subjected to histopathological studies as well as analyzed for liver antioxidants. Results: The results for biochemical markers revealed that the rats treated with the extract (500 mg/kg dose) showed a maximum elevation of catalase (48.90 µmole of H2O2 consumed/min/mg protein), glutothione peroxidase (22.1 mg GSH consumed/min/mg protein), superoxide dismutase (14.2 units/min/mg protein), and a reduction in glutathione (18.1 µmole of GSH/mg protein). Serum biochemical parameters including serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphate (ALKP), and direct bilirubin were significantly (p < 0.01) increased in the treated groups. Oral administration of different doses of C. intybus seed extract significantly (p < 0.01) protected the hepatic cells from impairment. The biochemical markers and hematological parameters were also normal in extract-treated rats in contrast to the standard (silymarin) and control groups. Conclusion: The results show that C. intybus plant is potential a good natural source of natural hepatoprotective and antioxidants agents.

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Section: Sample and Extract Preparationmentioning

confidence: 99%

Antioxidant activity and hepatoprotective effect of <i>Cichorium intybus</i> (Kasni) seed extract against carbon tetrachloride-induced liver toxicity in rats

Khalid¹,

Shahid²,

Khan³

et al. 2018

Trop. J. Pharm Res

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“…The antimycotic propensity of the synthesized metal complex formazans (S1-S6) were evaluated against different mycological strains such as Trichophyton mentagrophytes (ATCC 9533), Candida albicans (ATCC 10231), Aspergillus niger (ATCC 16404), Saccharomyces cerevisiae (ATCC 9763) and Candida glabrata (ATCC 90030) adopting the standard protocol described by. [56,57] The employed fungal microorganisms were acquired from the microbiology laboratory of University of Veterinary and Animal Science Lahore, Pakistan. Terbinafine and Fluconazole were served as standard antimycotic drugs (positive control) for the comparative study of antimycotic propensity against different fungal strains.…”

Section: Antimycotic Activitymentioning

confidence: 99%

Synthesis, DFT, computational exploration of chemical reactivity, molecular docking studies of novel formazan metal complexes and their biological applications

Khan

Rızwan

Shahid

et al. 2020

Applied Organom Chemis

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The computational exploration of chemical reactivity and molecular docking of the synthesized formazan compounds (S1‐S6) were studied. Further, their antimicrobial activity against bacterial strains (S. epidermidis, B. cereus, K. pneumoniae and P. aeruginosa) and against fungal strains (T. mentagrophytes, C. albicans, A. niger, S. cerevisiae and C. glabrata) using agar diffusion method and antioxidant activity following DPPH inhibition assays were evaluated. Anticancer activity was executed in vitro model of human breast carcinoma (MCF‐7) cell line. The superior and enhanced antibacterial and antimycotic activities were exhibited by formazan compound (S4) by presenting maximum ZOIs and MICs values. While enhanced antioxidant in terms of percentage inhibition of DPPH and cytotoxic effect on human breast carcinoma‐cells demonstrated by formazan compound (S1) which was further validated by the results of molecular docking studies of (S1) with the human estrogen receptor protein. In order to compute quantum chemical reactivity descriptors from conceptual density functional theory (CDFT) point of view of this system, including chemical potential (μ), chemical hardness (η), electrophilicity (ω), condensed Fukui function and dual descriptors are calculated at the same level of calculation. The most active sites of these molecules are determined and correlated with experimental data. The present investigation displays that formazans compounds could be potential drug candidate that constrains the growth of microbial strains, possess ability to cause cytotoxic effect on carcinoma cells and act as effective scavenger for free radical species.

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“…(8) Taking into account the total concentration of dissolved acid and the Ka 1 and Ka 2 acid constants of HQx, the equilibrium concentrations of the H 2 Qx +, HQx and Qxspecies can be deduced, depending on the concentration of hydrogen ions, respectively, depending on pH, equations (9)(10)(11). (11) Correlating concentrations suggested by the relationships (4-11) with the constants for studied ions complexes formation with 8-hydroxyquinoline [31,34] it (4) can be illustrated which ions will be separated depending on the pH of the receiving phase ( fig. 6).…”

Section: Determination Of Ph and Optimal Working Timementioning

confidence: 99%

Iono-molecular Separation with Composite Membranes. VIII. Recuperative aluminium ions separation on capilary Polypropylene S-EPDM composite membranes

Nafliu¹,

Al-Ani²,

Grosu³

et al. 2019

Mat.Plast.

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Environmental problems occurring in isolated or hardly accessible inhabited areas can be adequately addressed using membranes and membrane processes.In the present paper, the recuperative separation of aluminum ion from the aluminum sulfate-treated water through permeation using capillary composite membranes, from polypropylene with ethylene propylene diene terpolymer sulfonic acid (PP / S-EPDM) inclusions is followed by the reaction of complexation with 8-hydroxy quinoline. The installation used for studying the permeation process provides a usable surface area of 1 m2, the source phase solution volume is 3 L, and the receiving phase is 300 mL. The two phases are recirculated through the outside of the membranes (SP) and respectively through membranes (RP), by means of individual peristaltic pump that can provide flow variations between 2 and 200 mL / min by varying the intensity of the power supply. The optimal operating parameters were determined: operating time, pH and receiving phase flow, thus achieving an ionic flux (IR) above 10-11 mol / cm 2. s and a recovery factor (RF) over 90%.

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Synthesis, characterization and pharmacological evaluation of mixed ligand-metal complexes containing omeprazole and 8-hydroxyquinoline

Cited by 27 publications

References 20 publications

Antioxidant activity and hepatoprotective effect of <i>Cichorium intybus</i> (Kasni) seed extract against carbon tetrachloride-induced liver toxicity in rats

Antioxidant activity and hepatoprotective effect of <i>Cichorium intybus</i> (Kasni) seed extract against carbon tetrachloride-induced liver toxicity in rats

Synthesis, DFT, computational exploration of chemical reactivity, molecular docking studies of novel formazan metal complexes and their biological applications

Iono-molecular Separation with Composite Membranes. VIII. Recuperative aluminium ions separation on capilary Polypropylene S-EPDM composite membranes

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