Synthesis, crystal structure, theoretical calculation and cytotoxic effect of new Pt(ii), Pd(ii) and Cu(ii) complexes with pyridine-pyrazoles derivatives

Tautomeric forms study of 1H-(2′-pyridyl)-3-methyl-5-hydroxypyrazole and 1H-(2′-pyridyl)-3-phenyl-5-hydroxypyrazole. Synthesis, structure, and cytotoxic activity of their complexes with palladium(II) ions

“…The angle N1-Pd-N3 (80.57(9)°) of the chelate ligand is the smallest, then follows the angle Cl1-Pd-Cl2 (88.33(3)°), whereas the two angles Cl1-Pd-N1 (94.25(6)°) and Cl2-Pd-N3 (96.94(7)°) are significantly larger than 90°. This may be due to the small angle of the N,N9-chelate system and corresponds to values found earlier in a similar Pd-complex 51 and also in complex 4. The trans ligands form angles Cl1-Pd-N1 and Cl2-Pd-N3 of about 175°.…”

Platinum(II) and palladium(II) complexes with (N,N′) and (C,N,N′)− ligands derived from pyrazole as anticancer and antimalarial agents: Synthesis, characterization and in vitro activities

“…All reactions were carried out with dry and freshly distilled solvents. Column chromatography refers to flash chromatography and was carried out on SiO 2 (13); N(1)\C(1),1.339 (6); N(1)\N(2), 1.370 (6); N(3)\C(7), 1.499 (5); N(3)\C(6), 1.499 (7); N(3)\C(8), 1.506(6); C(1)\C(2), 1.409(8); C (2)\C(3), 1.367(10); C(3)\N(2), 1.349 (7); N(2)\C(5), 1.453(7); C(5)\C(6), 1.483 (7); N (1)\Pt\N(3), 93.57 (15); N(1)\Pt\Cl(1), 176.60 (11), N(3)\Pt\Cl(1), 89.61 (12); N (1)\Pt\Cl(2), 89.32 (12) ). (from 2% to 5%)} to yield 28 mg ( …”

“…In addition, it is well-known that azoles are valuable reagents in coordination chemistry and that their binding to a transition metal ion affects their properties and activities. Few complexes with pyrazole ligands showing an antitumor activity similar to that of cisplatin have been reported [11][12][13][14][15][16][17][18][19][20], but the effect produced by the substituents on the heterocycle has not been clarified so far. Within this therapeutic context, and in order to clarify this point and to elucidate the influence of mode of binding of this family of ligands in the biological activity of the complexes, we decided to synthesize the new pyrazole derivatives 1a-1c ( Fig.…”

Copper(II) complexes with N-(2-hydroxyethyl)-2-iminodiacetic acid and imidazoles: crystal structure, spectroscopic studies and superoxide dismutase activity

“…Some of them have shown significant cytotoxic activity [4]. Imidazole is of considerable interest as a ligand due to its presence in many biological systems.…”