Copper(II) complexes with N-(2-hydroxyethyl)-2-iminodiacetic acid and imidazoles: crystal structure, spectroscopic studies and superoxide dismutase activity

Abstract

Two new copper(II) complexes, [Cu(Hhida)-(BenzImH)]ÁH 2 O (1) and [Cu(Hhida)(EtImH)]Á2H 2 O (2) have been synthesized by the interaction of basic copper carbonate with N-(2-hydroxyethyl)-2-aminodiacetic acid (Hhida 2-) and benzimidazole (BenzImH) or (2-ethylimidazole (EtImH)). The structures of both complexes were studied by single crystal X-ray diffraction. The geometry around the copper(II) atom can be best described as distorted square pyramidal as indicated by the value of the trigonal index s = 0.32 for (1) and 0.21 for (2). Spectroscopic and electrochemical studies were performed in order to correlate structural features of the complexes with their superoxide scavenger activity. The ability of the complexes to scavenge superoxide anions was also evaluated.

Complexes of N-hydroxyethyl-N-benzimidazolylmethylethylenediaminediacetic acid with group 12 metals and vanadium—Synthesis, structure and bioactivity of the vanadium complex

“…The concentration of PTP1B was 60 nm, with fixed substrate concentration of 2.0 mM and the concentrations of oxovanadium complex (II) ranging between 1 nM and 10 mM.3. Results and discussionNIR spectra of all complexes in the 650-150 cm −1 region were measured and assigned according to data of analogous complexes found in the literature[16,[40][41][42][43]. The Cd-N frequencies were assigned to 431 and 456 cm −1 , respectively (aliphatic N atoms), and 278 cm −1 (N from benzimidazole); the Cd-O stretching frequency to 226 cm −1 .…”

Studies of Distorted Octahedral Complexes of Cobalt, Nickel and Copper and Their Antibacterial Properties

“…The enhancement of biological activity of the ligand after complexation may be attributed by chelate formation which fascinates the complex across the cell memebrance. [63][64][65] These bands has been assigned to the following spin allowed transition with their energy 57 .…”

New modulated design and synthesis of quercetin–CuII/ZnII–Sn2IV scaffold as anticancer agents: in vitro DNA binding profile, DNA cleavage pathway and Topo-I activity

“…For a copper complex the g k parameter is sensitive enough to indicate covalence. 21 For a covalent Cu II complex g k < 2.3 and for an ionic environment, normally g k = 2.3 or more. The g values obtained for this complex were found to be less than 2.3 consistent with metal ligand covalent character.…”