Synthesis, crystal structure, magnetic property and DNA cleavage activity of a new terephthalate-bridged tetranuclear copper(II) complex

Dhara, Koushik; Roy, Partha; Ratha, Jagnyeswar; Manassero, Mario; Banerjee, Pradyot

doi:10.1016/j.poly.2007.06.009

Cited by 98 publications

(37 citation statements)

References 62 publications

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“…Figure 5 shows the Stern-Volmer plot where good upward linear relationship (r=0.996) is seen upon binding CT-DNA with increasing concentration of conjugate. The fluorescence intensity of EtBr is quenched by the addition of conjugate due to the decrease in the binding sites of DNA available for EtBr [32]. Since EtBr interacts with DNA through intercalation into the minor groove, its displacement by compound indicates an intercalative type of binding [33] where conjugate intercalates into the adjacent base pairs of DNA easily.…”

Section: Change In Secondary Structure Of Hsa In Presence Of 26p-olamentioning

confidence: 99%

Biophysical Interactions of Novel Oleic Acid Conjugate and its Anticancer Potential in HeLa Cells

et al. 2015

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Novel conjugate 2,6-Diisopropylphenol-Oleic acid (2,6P-OLA) has shown potent anticancer activity on various cancer cell lines (Khan et al. Lipids 47:973-986, 2012). In the present study, the protein-or/ and DNA-binding property of 2,6P-OLA was evaluated that could predict its potential toxic effect, in vitro. Preferential structural stability and interaction mechanism of 2,6P-OLA to human serum albumin (HSA) and calf thymus DNA (CT-DNA) was used as model molecules, employing fluorescence spectroscopy (FS) and circular dichroism (CD) methods. The binding and apoptotic activities of conjugate were determined on bacterial recombinant DNA, pBR322 and human cancer cell line, HeLa, respectively. FS studies showed a strong conjugate binding affinity to HSA with overall binding constant of K = 7.66 (±0.03) × 10(2) M(-1). Higher concentration induced detectable changes in the CD spectrum of HSA. The conjugate complexation altered HSA secondary conformation by an increase in α-helices and decrease in β-sheets. Flourescence quenching studies with CT-DNA exhibited K = 1.215 × 10(2) L mol(-1) where 2,6P-OLA efficiently displaced the ethidium bromide (EtBr) bound DNA indicating its strong competition with EtBr for intercalation. Similarly, 2,6P-OLA was able to partially bind pBR322, resulting in decrease the intensity of EtBr gradually. The conjugate significantly reduced survival of HeLa cells. Morphological studies revealed altered cell morphology, suggesting apoptotic death of HeLa cells. Overall, our data shows that 2,6P-OLA bind well with both HSA and DNA and possessed anticancer activities.

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Section: Change In Secondary Structure Of Hsa In Presence Of 26p-olamentioning

confidence: 99%

Biophysical Interactions of Novel Oleic Acid Conjugate and its Anticancer Potential in HeLa Cells

et al. 2015

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“…In efforts to craft novel polynuclear lanthanide clusters showing slow relaxation of magnetization, Tang et al achieved an unparalleled hexanuclear dysprosium cluster (11) (Ke et al, 2011) using 1,3-bis(salicylideneamino)-2-propanol (H 3 L) as ligand, which was well-recognized as a versatile chelating and bridging group taking part in the formation of quite a few number of 3d metal clusters (Mukherjee et al 2005;Dhara et al, 2007;Lu et al, 2009). Interestingly, from a structural point of view, complex 11 indicated an unprecedented "edge-to-edge" arrangement of two Dy 3 triangles.…”

Section: Homonuclear Ln 6 Smmsmentioning

confidence: 99%

Recent Progress in the Realm of Homonuclear Ln6 Single molecule magnets: Structural Overview and Synthetic Approaches

Mukherjee

Ghosh²

2015

Proceedings of the Indian National Science Academy

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The synthetic approaches to design hexanuclear Lanthanide-based single molecule magnets are demonstrated in detail. Extensive analysis of the reported hexanuclear systems provides vital insight for controlling the relaxation dynamics of Ln(III)-based SMMS. The assembly of hexanuclear lanthanide-based SMMs employing several ligands is summarized. Favorable structural units could be exploited as motifs in the formation of novel Ln(III)-based SMMs, slow magnetic relaxation feature being the principal focus for them. This review will span a number of hexanuclear homometallic 4f-complexes, which have been critical in the understanding of the manner in which the lanthanide centers in a complex interact magnetically. Heterometallic 3d-4f complexes which also present hexanuclearity are purposefully evaded to merely streamline and simplify the discussion in a much focused manner. Hexanuclear lanthanide model has particularly been the recent focus of attention to study and comprehend the magnetic coupling in 4f systems. This is to draw imperative conclusions concerning the most effective super-exchange pathways permitting the most efficient intracomplex interactions by demonstrating the research developed in the last few years on the fascinating field of Ln 6 -based SMMs with precise emphasis on how recent studies tend to address the issue of relaxation dynamics in these systems from synthetic point of view.

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“…It is well known that modes of DNA non-covalent interaction with metal complexes include electrostatic effect, groove binding and intercalation; and effectiveness mainly depends on the mode and affinity of the binding between the complexes and DNA [8,9]. Along this line, many of transition metal complexes have been synthesized and their interactions with DNA studied [10][11][12][13][14][15][16][17][18][19]. Furthermore, significant developments have occurred in recent years in the chemistry of polymer-metal complexes.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Structure, Cytotoxic Activities and DNA-Binding Properties of a 1D Copper(II) Complex Bridged both by Oxamidate and Terephthalato Groups

Jiang

et al. 2012

J Inorg Organomet Polym

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A new one-dimensional copper(II) polymer with formula of [Cu 2 (heae)(tpa)] n ÁnH 2 O, where heae 2-and tpa 2-stand for the dianions of N,N 0 -bis(N-hydroxyethylaminoethyl)oxamide and terephthalic acid, respectively, has been synthesized and characterized by elemental analysis, conductivity measurement, IR and electronic spectral studies, and single-crystal X-ray diffraction. The crystal structure consists of a one-dimensional copper(II) coordination polymeric chain constructed by the [Cu 2 (heae)] 2? cations as the inorganic second building units (SBUs) and the tpa 2-anions as linkers. The CuÁÁÁCu separations through the bridges of heae 2-and tpa 2-are 5.2472(6) and 10.9677(8) Å , respectively. Both the copper(II) ions have square pyramidal coordination geometries. A three-dimensional hydrogen bonding network is observed in the crystal. The measured molar conductivity suggests that the polymer may stay intact in solution as the 1D polymer in the crystal. The cytotoxicities of the polymeric copper(II) complex were tested by Sulforhodamine B (SRB) assays against human hepatocellular carcinoma cell SMMC-7721 and human lung adenocarcinoma cell A549. The polymer exhibits potent cytotoxic effects against the two cell lines. The binding properties of the copper(II) polymer with herring sperm DNA (HS-DNA) have been investigated by using UV absorption and fluorescence spectra and electrochemical techniques and viscosity. The results show that the copper(II) polymer interacts with HS-DNA in the mode of intercalation with the intrinsic binding constant of 1.07 9 10 4 M -1 .

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Synthesis, crystal structure, magnetic property and DNA cleavage activity of a new terephthalate-bridged tetranuclear copper(II) complex

Cited by 98 publications

References 62 publications

Biophysical Interactions of Novel Oleic Acid Conjugate and its Anticancer Potential in HeLa Cells

Biophysical Interactions of Novel Oleic Acid Conjugate and its Anticancer Potential in HeLa Cells

Recent Progress in the Realm of Homonuclear Ln6 Single molecule magnets: Structural Overview and Synthetic Approaches

Synthesis, Structure, Cytotoxic Activities and DNA-Binding Properties of a 1D Copper(II) Complex Bridged both by Oxamidate and Terephthalato Groups

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