Synthesis, Crystal Structure, Antioxidant, Antimicrobial, and Mutagenic Activities and DNA Interaction Studies of Ni(II) Schiff Base 4-Methoxy-3-benzyloxybenzaldehyde Thiosemicarbazide Complexes

Abstract

Three new Ni(II) square planar complexes of 4-methoxy-3-benzyloxybenzaldehyde thiosemicarbazide(4m3BTSC) having polypyridyl bases of general formulation [ML2] (1) and [MLB] (2, 3), where L = 4m3BTSC and B is N,N-donor heterocyclic bases, namely, 1,10-phenanthroline (phen, 2), 2,2′-bipyridine (bpy, 3), are synthesized and characterized. The free radical scavenging assay results showed that complex 1 possesses significant activity when compared to complexes 2 and 3. The biological studies showed that the ligand and its complexes exhibited significant and different biological activities and also the prepared compounds are nonmutagenic. They may be potential commercial antioxidants because of their nonmutagenic and nontoxic nature. The DNA interaction of the new complexes is evaluated by absorption, emission, and melting temperature methods, and the results suggested that the binding affinity of the complexes increases with the presence of planar ligand in the molecule. The nickel (II) complexes with planar phenanthroline bases show moderate DNA binding and cleavage ability.

Synthesis of a DNA-targeting nickel (II) complex with testosterone thiosemicarbazone which exhibits selective cytotoxicity towards human prostate cancer cells (LNCaP)

“…Apart from cytotoxicity against a few cancer cell lines, abilities of the synthesized compounds to bind and interact with DNA were investigated and reported herein as a preliminary effort to unravel their potential biological properties. Enhanced DNA binding ability upon complexation with nickel ion is anticipated because square planar structure usually permits better stacking interaction with the base pairs of DNA double helix [22].…”

Hetero-Binuclear Complexes of Lanthanum (Iii) Using Bridging N,n?-Bis(2-Pyridylmethyl)oxamide and Terminal 1,10-Phenanthroline: Synthesis, Characterization and Biological Evaluation

“…A classical intercalator intercalates between the base pairs of the DNA, thus increases the length of DNA helix and hence viscosity of DNA increases whereas partial or non-classical interaction of complex results in bending or kinking of DNA, thereby decreasing the length of the DNA and in turn decreases the viscosity of DNA. [41,46,55] The concentration dependent viscosity method reveals that, as the concentration of the complexes increases, viscosity of the DNA increases. The viscosity is highest for binuclear complexes (5 and 6) than their mononuclear analogues (2)(3)(4).…”

“…DPPH has an absorbance of 517 nm in its radical form that disappears after accepting hydrogen radical or electron from the antioxidant and becomes a stable diamagnetic substance. [46][47] The DPPH radical scavenging ability of the synthesized ligand 2PMO (1) and its complexes (2-6) were determined by modifying the method reported by Brand-Williams et al [57] 1 mg mL -1 stock solutions were prepared by dissolving 2PMO (1) and its complexes (2-6) in DMF. Test solutions (10-70 µg mL -1 ) were taken in 96-well plate and the volumes were made up to 200 µL using 5 mM Tris-HCl buffer (pH = 7.4).…”

A STUDY OF CORROSION INHIBITION EFFECT OF PYRIDINE BASED SCHIFF BASE ON IRON METAL IN 0.5M HCl

“…Corrosion has direct and indirect impact on economy, environment, materials and lives. It causes huge losses to building, automobiles, industries and their services [1][2][3][4][5][6][7]. Iron and its alloys which are widely used in a lot of industrial processes could corrode during these acidic applications particularly with the use of hydrochloric acid and sulphuric acid [8].…”