“…One of the most important reasons is that the large size of the LNP crystal is too difficult to grow. In the past 40 years, two methods, including the high-temperature solution method [9][10][11] and ux method, [12][13][14] were used to grow LNP single crystals. Compared to the high-temperature solution method, the ux method has many outstanding advantages, such as wider applicability, simpler device, lower growing temperature and higher crystalline quality, so it has become the main method for preparing LNP crystal.…”