Synthesis, copolymerization and peptide-modification of carboxylic acid-functionalized 3,4-ethylenedioxythiophene (EDOTacid) for neural electrode interfaces

Povlich, Laura K.; Cho, Jae Cheol; Leach, Michelle K.; Corey, Joseph M.; J, Kim; Martin, David C.

doi:10.1016/j.bbagen.2012.10.017

Cited by 75 publications

(86 citation statements)

References 20 publications

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“…On interaction of the matter in solution with the substrate on the sensor crystal, the changes in the resonance frequency of the sensor (Df), which is related to the attached mass, were recorded at a resolution of less than 1 s. If necessary, the pump was stopped for a few seconds to change the sample solutions without disturbing the QCM-D signal. The resonance frequencies were measured simultaneously at 5 MHz and its five harmonics (15,25,35,45,55 and 65 MHz). If not stated otherwise, changes in frequency of the third overtone (n ¼ 3; that is, 15 MHz) are presented.…”

Section: Methodsmentioning

confidence: 99%

“…To resolve this issue, several groups have focused on tuning the biological and physical functions of ECPs through chemical modification or dopant switching. For example, Povlich et al 45 conjugated RGD peptide onto PEDOT chemically and observed that the new polymer could induce neural differentiation. Although the introduction of oligopeptide ligands (for example, YIGSR 46 , RGD), collagen 31 , or nerve growth factor 21 can enhance cell-material interactions, thereby stabilizing cell proliferation and differentiation, no corresponding decreases in immunogenic response have been observed 43,46 .…”

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confidence: 99%

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Large enhancement in neurite outgrowth on a cell membrane-mimicking conducting polymer

et al. 2014

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Although electrically stimulated neurite outgrowth on bioelectronic devices is a promising means of nerve regeneration, immunogenic scar formation can insulate electrodes from targeted cells and tissues, thereby reducing the lifetime of the device. Ideally, an electrode material capable of electrically interfacing with neurons selectively and efficiently would be integrated without being recognized by the immune system and minimize its response. Here we develop a cell membrane-mimicking conducting polymer possessing several attractive features. This polymer displays high resistance towards nonspecific enzyme/cell binding and recognizes targeted cells specifically to allow intimate electrical communication over long periods of time. Its low electrical impedance relays electrical signals efficiently. This material is capable to integrate biochemical and electrical stimulation to promote neural cellular behaviour. Neurite outgrowth is enhanced greatly on this new conducting polymer; in addition, electrically stimulated secretion of proteins from primary Schwann cells can also occur on it.

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

Large enhancement in neurite outgrowth on a cell membrane-mimicking conducting polymer

et al. 2014

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“…Conducting polymer coatings are known to dramatically decrease electrode impedance and increase charge injection limit [18, 106], and have been used to enable recording from ultrasmall electrode sites [47, 107]. New advances in conducting polymers may be found in novel dopants [61, 89], drug delivery [89], and novel monomers and crosslinkers for ease of functionalization or improved stability [108–111]. These novel polymer coatings may allow for further decreased size of both recording and stimulating electrodes for central and peripheral nervous system applications.…”

Section: Strategiesmentioning

confidence: 99%

Recent advances in neural electrode–tissue interfaces

Woeppel

Yang

Cui

2017

Current Opinion in Biomedical Engineering

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Neurotechnology is facing an exponential growth in the recent decades. Neural electrode-tissue interface research has been well recognized as an instrumental component of neurotechnology development. While satisfactory long-term performance was demonstrated in some applications, such as cochlear implants and deep brain stimulators, more advanced neural electrode devices requiring higher resolution for single unit recording or microstimulation still face significant challenges in reliability and longevity. In this article, we review the most recent findings that contribute to our current understanding of the sources of poor reliability and longevity in neural recording or stimulation, including the material failure, biological tissue response and the interplay between the two. The newly developed characterization tools are introduced from electrophysiology models, molecular and biochemical analysis, material characterization to live imaging. The effective strategies that have been applied to improve the interface are also highlighted. Finally, we discuss the challenges and opportunities in improving the interface and achieving seamless integration between the implanted electrodes and neural tissue both anatomically and functionally.

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“…[10][11][12] Among the available CPs utilized for clinical applications, poly(3,4-ethylenedioxythiophene) (PEDOT) has drawn wide interest in the biomedical eld due to its unique environmental stability as well as noticeable biocompatibility, easy synthesis with less expensive route, high charge mobility and thermal stability with high electrical redox properties. 13,14 Moreover, among the available CPs, only PEDOT is manufactured industrially and traded globally for numerous applications. 15 It has been recently indicated that the aqueous compatibility and biocompatibility of PEDOT are good in physiological environments and that the polymerization of EDOT molecules has also been directly performed in physical muscles due to its high biocompatibility arising from structural resemblance with natural constituents similar to melanin.…”

Section: -9mentioning

confidence: 99%

Influence of surface treatment on PEDOT coatings: surface and electrochemical corrosion aspects of newly developed Ti alloy

et al. 2018

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Surface treatment of metallic materials prior to the application of polymer coatings plays an important role in providing improved surface features and enhanced corrosion protection. In the current investigation, we aimed to evaluate the effect of surface treatment of newly developed TiNbZr (TNZ) alloys on the surface characteristics, including the surface topography, morphology, hydrophobicity and adhesion strength of subsequent poly(3,4-ethylenedioxythiophene) (PEDOT) coatings. The surface morphology, chemical composition, and surface roughness of both treated and coated alloys were characterized by scanning electron microscopy, energy dispersive spectroscopy, and optical profilometry, respectively. The adhesion strength of the coating was measured using a micro scratch machine. Furthermore, we also evaluated the performance of electrochemically synthesized PEDOT coatings on surface-treated TNZ alloys in terms of the surface protective performance in simulated body fluid (SBF) and in vitro bioactivity in osteoblast MG63 cells. Surface analysis findings indicated that the nature of the PEDOT coating (surface morphology, topography, wettability and adhesion strength) was intensely altered, while the surface treatment performed before electrodeposition facilitated the overall performance of PEDOT coatings as implant coating materials. The obtained corrosion studies confirmed the enhanced corrosion protection performance of PEDOT coatings on treated TNZ substrates. In vitro cell culture studies validated the improved cell adhesion and proliferation rate, further highlighting the important role of surface treatment before electrodeposition.

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Synthesis, copolymerization and peptide-modification of carboxylic acid-functionalized 3,4-ethylenedioxythiophene (EDOTacid) for neural electrode interfaces

Cited by 75 publications

References 20 publications

Large enhancement in neurite outgrowth on a cell membrane-mimicking conducting polymer

Large enhancement in neurite outgrowth on a cell membrane-mimicking conducting polymer

Recent advances in neural electrode–tissue interfaces

Influence of surface treatment on PEDOT coatings: surface and electrochemical corrosion aspects of newly developed Ti alloy

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