Recent advances in neural electrode–tissue interfaces

Woeppel, Kevin; Yang, Qianru; Cui, Xiufang

doi:10.1016/j.cobme.2017.09.003

Cited by 83 publications

(59 citation statements)

References 109 publications

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“…Conducting polymers have gained substantial attention in recent years as an advanced coating for microelectrodes, with particular emphasis on the polypyrrole and poly(3,4‐ethylenedioxythiophene) (PEDOT). Conducting polymer coatings can be electrochemically deposited on an electrode by immersing the electrode site in a solution of monomer alongside a negatively charged dopant.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle Doped PEDOT for Enhanced Electrode Coatings and Drug Delivery

Woeppel

Zheng

Schulte

et al. 2019

Adv Healthcare Materials

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In order to address material limitations of biologically interfacing electrodes, modified silica nanoparticles are utilized as dopants for conducting polymers. Silica precursors are selected to form a thiol modified particle (TNP), following which the particles are oxidized to sulfonate modified nanoparticles (SNPs). The selective inclusion of hexadecyl trimethylammonium bromide allows for synthesis of both porous and nonporous SNPs. Nonporous nanoparticle doped polyethylenedioxythiophene (PEDOT) films possess low interfacial impedance, high charge injection (4.8 mC cm−2), and improved stability under stimulation compared to PEDOT/poly(styrenesulfonate). Porous SNP dopants can serve as drug reservoirs and greatly enhance the capability of conducting polymer‐based, electrically controlled drug release technology. Using the SNP dopants, drug loading and release is increased up to 16.8 times, in addition to greatly expanding the range of drug candidates to include both cationic and electroactive compounds, all while maintaining their bioactivity. Finally, the PEDOT/SNP composite is capable of precisely modulating neural activity in vivo by timed release of a glutamate receptor antagonist from coated microelectrode sites. Together, this work demonstrates the feasibility and potential of doping conducting polymers with engineered nanoparticles, creating countless options to produce composite materials for enhanced electrical stimulation, neural recording, chemical sensing, and on demand drug delivery.

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Section: Introductionmentioning

confidence: 99%

Nanoparticle Doped PEDOT for Enhanced Electrode Coatings and Drug Delivery

Woeppel

Zheng

Schulte

et al. 2019

Adv Healthcare Materials

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“…Besides, polyaniline, polythiophene derivatives such as PEDOT:PSS are also well‐established for electreophysiological signals. One more thing to be considered is the toxic residual monomers or oligomer and stability of electroactive polymers which might be adverse for constructing biocompatible interfaces …”

Section: Stretchable and Conformal Sensors For Cyber Biophysical Intementioning

confidence: 99%

Cyber–Physiochemical Interfaces

et al. 2020

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Living things rely on various physical, chemical, and biological interfaces, e.g., somatosensation, olfactory/gustatory perception, and nervous system response. They help organisms to perceive the world, adapt to their surroundings, and maintain internal and external balance. Interfacial information exchanges are complicated but efficient, delicate but precise, and multimodal but unisonous, which has driven researchers to study the science of such interfaces and develop techniques with potential applications in health monitoring, smart robotics, future wearable devices, and cyber physical/human systems. To understand better the issues in these interfaces, a cyber–physiochemical interface (CPI) that is capable of extracting biophysical and biochemical signals, and closely relating them to electronic, communication, and computing technology, to provide the core for aforementioned applications, is proposed. The scientific and technical progress in CPI is summarized, and the challenges to and strategies for building stable interfaces, including materials, sensor development, system integration, and data processing techniques are discussed. It is hoped that this will result in an unprecedented multi‐disciplinary network of scientific collaboration in CPI to explore much uncharted territory for progress, providing technical inspiration—to the development of the next‐generation personal healthcare technology, smart sports‐technology, adaptive prosthetics and augmentation of human capability, etc.

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“…3(b)). This results in a false neural signal (or, noise) V NT from undesired cells [54], [55]. In addition, the amplitude of the neural recording is diminished due to the low impedance shunting pathways of the neighbourhood condition.…”

Section: B Interruption In Probe/tissue Circuit Due To Implantation mentioning

confidence: 99%

Biointegrated and Wirelessly Powered Implantable Brain Devices: A Review

Das

Moradi

Heidari

2020

IEEE Trans. Biomed. Circuits Syst.

117

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Implantable neural interfacing devices have added significantly to neural engineering by introducing the lowfrequency oscillations of small populations of neurons known as local field potential as well as high-frequency action potentials of individual neurons. Regardless of the astounding progression as of late, conventional neural modulating system is still incapable to achieve the desired chronic in vivo implantation. The real constraint emerges from mechanical and physical differences between implants and brain tissue that initiates an inflammatory reaction and glial scar formation that reduces the recording and stimulation quality. Furthermore, traditional strategies consisting of rigid and tethered neural devices cause substantial tissue damage and impede the natural behavior of an animal, thus hindering chronic in vivo measurements. Therefore, enabling fully implantable neural devices requires biocompatibility, wireless power/data capability, biointegration using thin and flexible electronics, and chronic recording properties. This article reviews biocompatibility and design approaches for developing biointegrated and wirelessly powered implantable neural devices in animals aimed at long-term neural interfacing and outlines current challenges toward developing the next generation of implantable neural devices.Index Terms-Biocompatibility, biointegration, implantable neural device, mechanical flexibility, wireless power transfer.

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Recent advances in neural electrode–tissue interfaces

Cited by 83 publications

References 109 publications

Nanoparticle Doped PEDOT for Enhanced Electrode Coatings and Drug Delivery

Nanoparticle Doped PEDOT for Enhanced Electrode Coatings and Drug Delivery

Cyber–Physiochemical Interfaces

Biointegrated and Wirelessly Powered Implantable Brain Devices: A Review

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