Synthesis conditions and characterization of superparamagnetic iron oxide nanoparticles with oleic acid stabilizer

Abstract

Superparamagnetic iron oxide nanoparticles (SPIONs), part of magnetic nanoparticles, have been widely used in biomedical applications. Biocompatibility and magnetic properties make the SPIONs developed further by a lot of researchers. However, in the synthesis process, SPIONs can run into agglomeration. Oleic acid (OA) is one of the stabilizers to prevent agglomeration. This research aims to optimize the synthesis conditions and characterization of SPIONs with OA as a stabilizer. The synthesis of Superparamagnetic Iron Oxide Nanoparticles-Oleic Acid (SPIONs-OA) was performed using the coprecipitation method and was prepared with the addition of 0.75, 1.5, and 3% v / v OA and stirring rate of 750, 1500, 3000, 6000, 9000, and 12,000 rpm. The characterization of hydrodynamic size and polydispersity index was evaluated by dynamic light scattering. Meanwhile, the crystal structure was observed by X-ray diffraction. Then, Fourier transform infrared spectroscopy (FTIR) was used to analyze structures. The results showed that the hydrodynamic size was dependent on OA concentrations and stirring rate. The addition of 1.5% v / v OA and stirring conditions of 750 rpm resulted in the smallest hydrodynamic size and polydispersity index (83.71 ± 0.70 nm and 0.215 ± 0.01 nm, respectively). Based on the crystal structure analysis, the crystal shape was magnetic cubic, and the size of Fe 3 O 4 crystallite changed from 11.38 to 5.61 nm. The FTIR indicated a strong chemical bond between the hydroxyl group of SPIONs and carboxylic acid of OA. In conclusion, the SPIONs-OA was successfully prepared with 1.5% v / v OA concentrations and a stirring rate of 750 rpm.

The effect of (3-aminopropyl) triethoxysilane and curcumin coating on the physicochemistry of Fe 3 O 4 particles as theranostics of oral cancer: qualitative study descriptive

“…hydrothermal, sol-gel), we could not successfully synthesize SPION in nanometer range since the growth in precipitation is uncontrolled. As for the particle size, it does not illustrate the real size of the particle as the particle is covered by the hydroxyl group found in the liquid.26 25 Besides the hydrodynamic diameter, the zeta potential value of the three samples (Figure 3) does not show significant difference. The high negative load of the three samples shows that the particles contain numerous hydroxyl groups on their surface and thus are not easily aggregated; loads between ±30 and 40 mV are categorized as moderately stable.…”

Composition, features, problems, and treatment related to cooling fluid – a review

“…The use of NCs in CSs may be hampered by the tendency of NPs to agglomerate, favoring the local accumulation of deposits in the flow channels, which may even lead to their clogging. The effect of the addition of oleic acid, which is one of the stabilizers preventing NPs agglomeration [170] is not well recognized in the case of NCs. In addition, the influence of adding NPs to base coolants on changing their toxicity is unknown.…”

Simultaneous therapeutic and diagnostic applications of magnetic PLGA nanoparticles loaded with doxorubicin in rabbit

“…In this study, the mentioned NPs were reproduced again in order to evaluate their physicochemical properties in vitro and in vivo in rabbit. Firstly, SPIONs (as diagnostic agents) are synthesized and stabilized by oleic acid (OA) via a co-precipitation method (37)(38)(39). Then, DOX and SPIONs are co-encapsulated into the polymeric PLGA-PEG matrix by a double emulsion method (W1/O/W2 11 ) (40)(41)(42).…”