The effect of (3-aminopropyl) triethoxysilane and curcumin coating on the physicochemistry of Fe 3 O 4 particles as theranostics of oral cancer: qualitative study descriptive

Abstract

Introduction: Superparamagnetic iron oxide nanoparticles (SPION) have been used in MRI and have the capability to conjugate with different ligands. One of the active ingredients of interest in biomedical applications is curcumin (Cur), which has been sho wn to have anti-inflammatory effects, wound healing properties, and anti-cancer activity. However, such conjugation may need to be facilitated by polymers, such as 3-aminopropyltrimethoxysilane (AMPTS). This study aims to describe the effect of coating materials (AMPTS and Cur) on the physicochemistry of Fe3O4 particles as a diagnostic of oral cancer. Methods: this research employed descriptive research. Modified SPIONs were synthesized by a simple coprecipitation method. In a molar ratio of 2:1, Fe 3+ and Fe 2+ were dissolved and mixed in 40 ml of water. The mixture was then heated at 40 °C until a brown precipitate was formed. AMPTS and Curcumin (20 mg/ml DMSO) were added for modifications. Fe3O4 particles were characterized using Fourier transform infrared spectroscopy (FTIR) to analyze the conjugation yield. Modified SPIONs were analyzed using dynamic light scattering (DLS) to examine their size distribution. Furthermore, the zeta potential of the particles was examined. Results: DLS showed size increases after modification of SPION with different materials. In addition, there were slight changes in zeta potential. However, FTIR showed no differences in peaks, indicating that no conjug ation was successful. Conclusion: Although FTIR showed no differences in peaks, DLS and zeta potential showed changes with different coatings, which may indicate conjugation. However, further analyses must be carried out to quantify the conjugation yield.