Synthesis, characterization, X-ray crystallography and DNA binding activities of Co(III) and Cu(II) complexes with a pyrimidine-based Schiff base ligand

Abstract

Characterization, X-ray crystallography and DNA binding activities of Co(III) and Cu(II) complexes with a pyrimidine-based Schiff base ligand, Inorganica Chimica Acta (2015), doi: http://dx.doi.org/10.1016/j.ica. 2015.11.015 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Synthesis

Synthesis and physicochemical, DFT, thermal and DNA-binding analysis of a new pentadentate N3S2 Schiff base ligand and its [CuN3S2]2+ complexes

“…The resulting mixed solution of Cu(II)/CT-DNA was allowed to equilibrate for 10 min at RT for each experiment prior to carrying out the absorption measurement. [35][36][37][38][39]…”

“…Each sample was measured in triplicate and the average ow time was calculated. Data are presented as (h/h o ) 1/3 versus the binding ratio [Cu]/[DNA], [35][36][37][38][39][40][41] where h is the viscosity of DNA in the presence of the complex and h o is the viscosity of the pure DNA solution. The desired Cu(II) complexes were prepared by mixing an equivalent amount of N 3 S 2 with the hydrated CuX 2 salt in EtOH at RT under an atmosphere.…”

“…Absorption spectroscopy is considered to be one of the most useful methods to evaluate the DNA binding affinity of a molecule. [35][36][37][38][39][40] The affinity of complex 1 and 2 toward CT-DNA was investigated using the UV-Vis titration spectra recorded in Tris-HCl buffer solution. The UV-Vis spectra of the target compounds were expected to change upon drug-DNA binding.…”

“…Bathochromic red shi hypochromism interactions are commonly observed due to strong p-p stacking (aromatic-DNA base pairs) and indicate intercalative binding interactions. [38][39][40] To estimate the binding ability of the Cu(II) complexes, the intrinsic binding constant (K b ) was evaluated by monitoring the changes in the absorbance spectra verses the CT-DNA concentration using the following equation. [35][36][37][38] [DNA]/(3 a À 3 f ) ¼ [DNA] was used to calculate and compare the K b values obtained for complex 1 (Fig.…”

Synthesis of Novel VO(II)-Perimidine Complexes: Spectral, Computational, and Antitumor Studies

“…It is noticeable that complexation of vanadium with organic ligands minimizes unfavorable effects of its inorganic salts such as vanadyl sulfate while even maintains its potential benefits [ 14 ]. Furthermore, mimicking the biological activities in natural systems can be achieved by vanadium complexes which contain oxygen and nitrogen donor ligands; so identification of the structure of these complexes is regarded important [ 15 – 17 ]. Bioinorganic chemistry is a fast developing field of modern chemistry that uses Schiff bases and their transition metal complexes for a variety of applications, e.g., in biological, medical, and environmental sciences.…”