SYNTHESIS, CHARACTERIZATION, THEORETICAL AND BIOLOGICAL STUDIES OF A NEW MACROCYCLE SCHIFF BASE WHITH Co(II), Ni(II), Cu(II) AND Zn(II) COMPLEXES

Abstract

A new macrocycle Schiff base, by the reaction between benzene-1,2-diamine and 3-bromo-pentane-2,4-dione, is introduced and a series of its complexes with Co(II), Ni(II), Cu(II) and Zn(II) have been synthesized. FTIR, 1 H and 13 C NMR, and TGA, also biological activities of all complexes and the electronic spectral data have been investigated. The results show that there are no water molecules, also that macrocycle Schiff base is bonded to the metal ions through nitrogen atoms of four azomethine groups via an octahedral arrangement containing N4 tetra-dentate donor sites on planar and two Cl atoms occupying the other two opposed sites. The corresponding Cu(II) and Zn(II) complexes showed good antibacterial and antifungal activities. The molecular geometry, frontier molecular orbitals and Mulliken atomic charge of the compounds are investigated theoretically using DFT method.

Synthesis, Characterization, and Antibacterial Activity of Lanthanide Metal Complexes with Schiff Base Ligand Produced from Reaction of 4,4-Methylene Diantipyrine with Ethylenediamine

“…Schiff base compounds are azomethinecontaining compounds formed through a condensation reaction between primary amine and carbonyl compounds, and they were first reported by Hugo Schiff in 1864 [14][15][16]. Schiff base compounds are a significant and well-studied class due to their wide variety of biological uses, simplicity of manufacturing, chelating properties, and stability [17][18][19]. In addition to their unique properties and practical uses, Schiff bases are also particularly fascinating compounds that shield metal ions from the chemical environment by creating kinetically inert complexes.…”