Synthesis, characterization, photoluminescence, antiproliferative activity, and DNA interaction of cadmium(II) substituted 4′-phenyl-terpyridine compounds

DNA radiosensitization by terpyridine-platinum: damage induced by 5 and 10 eV transient anions

“…The interactions of Tpy-Pt with DNA is quite distinct from those of traditional platinum-based compounds due to the favored intercalation of the flat Tpy-Pt structure within G4 configurations via weak π–π interactions. 33,36 Being bifunctional, Tpy-Pt can still form interstrand and intrastrand CLs within the DNA helix, most likely between guanines, adenines or both, 92,93 as do cisplatin, carboplatin and oxaliplatin, 9–11 although monofunctional binding to G is also possible. 46,94 Tpy-Pt and Tpy-based complexes interact with the quadruplex configuration via three major pathways: firstly, by π–π interactions with two opposing faces of a G4; secondly, by direct intercalation into the lateral and diagonal loops of G4s and finally, through replacement of monovalent alkaline ions, which usually fill the central channels of three-dimensional G4s.…”

Chlorido(4′-chloro-2,2′:6′,2′′-terpyridine-κ3 N,N′,N′′)(trifluoromethanesulfonato-κO)zinc(II) acetonitrile monosolvate

“…Substituted terpyridines such as 4 0 -chloro-2,2 0 :6 0 ,2 00 -terpyridine continue to be recognized as useful chelating ligands for many transition-metal ions, including platinum(II) (Qin et al, 2019), copper(II) (Choroba et al, 2019), cadmium(II) (Li et al, 2020), and zinc(II) (Li et al, 2019). Metal complexes containing zinc(II) and substituted terpyridines as chelating ligand have been shown to have promising antitumor activity (Liang et al, 2019).…”

A New Concept of Enhancing the Anticancer Activity of Manganese Terpyridine Complex by Oxygen-Containing Substituent Modification

“…Therefore, they have important research and application prospects in the fields of luminescent materials, photodynamic therapy and chemical sensors [ 26 , 27 , 28 , 29 , 30 , 31 , 32 ]. After the success of cisplatin and carboplatin in cancer chemotherapy, other transition metal ions have been of great interest, since they are involved in many biological processes [ 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ]. Among them, manganese is used to synthesize new complexes that exhibit excellent antibacterial and antitumor activity [ 46 , 47 , 48 ].…”