Synthesis, characterization, molecular modeling and biological activity of mixed ligand complexes of Cu(II), Ni(II) and Co(II) based on 1,10-phenanthroline and novel thiosemicarbazone

Al-Jahdali, Mutlaq; El‐Sherif, Ahmed A.

doi:10.1016/j.ica.2013.06.040

Cited by 89 publications

(43 citation statements)

References 71 publications

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“…Whereas, the calculated values showed that the stability of the formed metal complexes than the ligand alone [56].…”

Section: Energy Components and Dipole Moment Of H 2 Shah And Its Metamentioning

confidence: 85%

Computational simulation and biological studies on 3-(2-(2-hydroxybenzoyl)hydrazono)-N-(pyridine-2-yl)butanamide complexes

Ibrahim

Zaky

Gomaa

et al. 2015

Journal of Molecular Structure

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“…Whereas, the calculated values showed that the stability of the formed metal complexes than the ligand alone [56].…”

Section: Energy Components and Dipole Moment Of H 2 Shah And Its Metamentioning

confidence: 85%

Computational simulation and biological studies on 3-(2-(2-hydroxybenzoyl)hydrazono)-N-(pyridine-2-yl)butanamide complexes

Ibrahim

Zaky

Gomaa

et al. 2015

Journal of Molecular Structure

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“…Mixed-ligand complexes have been extensively studied following recognition that they play an important role in biological processes and serve as suitable models for valuable information in the elucidation of enzymatic processes of biological relevance [7,8]. Also, these complexes showed significant antibacterial, antifungal, and anticancer activity [9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectral, X-ray diffraction, antimicrobial studies, and DNA binding properties of binary and ternary complexes of pentadentate N2O3 carbohydrazone ligands

Shebl

Khalil

2014

Monatsh Chem

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Two pentadentate carbohydrazone ligands, H 2 L 1 and H 2 L 2 , were prepared by the reaction of the bifunctional compound carbohydrazide with 2-hydroxy-5-nitrobenzaldehyde and 2-hydroxy-1-naphthaldehyde, respectively. Reactions of the ligands with oxovanadium(IV), cerium(III), thorium(IV), and dioxouranium(VI) ions yielded binary complexes. Reactions of the ligands with the dioxouranium(VI) ion in the presence of secondary ligands (8-hydroxyquinoline, glycine, salicylaldehyde, or benzoylacetone) yielded ternary complexes. The ligands and metal complexes were characterized by different techniques such as elemental and thermal analyses, IR, 1 H and 13 C NMR, electronic, ESR, mass spectra, and powder XRD as well as magnetic susceptibility and conductivity measurements. The coordinating sites are phenolic oxygen, azomethine nitrogen, and carbonyl oxygen. In complexes, the ligands act as dibasic pentadentate except ternary dioxouranium(VI) complexes, obtained using glycine or benzoylacetone, in which the ligands act as monobasic pentadentate. The XRD patterns for the H 2 L 1 ligand, its binary dioxouranium(VI) complex, and its 8-hydroxyquinoline ternary complex indicate crystalline nature and the grain size was estimated. The H 2 L 1 ligand and its binary complex have triclinic systems while the ternary complex has a monoclinic system with different unit-cell parameters. The ligands and some of their metal complexes showed antimicrobial activity toward some Gram-positive and Gram-negative bacteria, yeast (Candida albicans), and fungus (Aspergillus fumigatus), and MIC values were determined. The DNA binding properties of the oxovanadium(IV) complexes of H 2 L 1 and H 2 L 2 ligands were investigated by electronic absorption spectroscopy and viscosity measurements. The results indicated that these complexes bind to DNA via an intercalation binding mode with an intrinsic binding constant K b of 2.55 9 10 4 and 3 9 10 4 M -1 , respectively.

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“…Hence, the lipophilic character of the central metal atom is improved which brings about a higher capacity to penetrate the microorganisms through the lipid layer of the cell membrane. In addition, all metal complexes under the investigation estimate a large value of binding energy than L 1 that enhances the steadiness of these complexes [53]. Additionally, electrophilicity of all complexes is bigger than that of L 1 and that could be another target behind some complexes to exhibit the biggest strong antimicrobial activity than the ligand.…”

Section: Dipole Moment and Other Molecular Propertiesmentioning

confidence: 98%

New Square-Pyramidal Oxovanadium (IV) Complexes Derived from Polydentate Ligand (L<sup>1</sup>)

Hassoon¹,

Al‐Radadi²,

Nawar³

et al. 2016

OJIC

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Synthesis, characterization, molecular modeling and biological activity of mixed ligand complexes of Cu(II), Ni(II) and Co(II) based on 1,10-phenanthroline and novel thiosemicarbazone

Cited by 89 publications

References 71 publications

Computational simulation and biological studies on 3-(2-(2-hydroxybenzoyl)hydrazono)-N-(pyridine-2-yl)butanamide complexes

Computational simulation and biological studies on 3-(2-(2-hydroxybenzoyl)hydrazono)-N-(pyridine-2-yl)butanamide complexes

Synthesis, spectral, X-ray diffraction, antimicrobial studies, and DNA binding properties of binary and ternary complexes of pentadentate N2O3 carbohydrazone ligands

New Square-Pyramidal Oxovanadium (IV) Complexes Derived from Polydentate Ligand (L<sup>1</sup>)

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Synthesis, characterization, molecular modeling and biological activity of mixed ligand complexes of Cu(II), Ni(II) and Co(II) based on 1,10-phenanthroline and novel thiosemicarbazone

Cited by 89 publications

References 71 publications

Computational simulation and biological studies on 3-(2-(2-hydroxybenzoyl)hydrazono)-N-(pyridine-2-yl)butanamide complexes

Computational simulation and biological studies on 3-(2-(2-hydroxybenzoyl)hydrazono)-N-(pyridine-2-yl)butanamide complexes

Synthesis, spectral, X-ray diffraction, antimicrobial studies, and DNA binding properties of binary and ternary complexes of pentadentate N2O3 carbohydrazone ligands

New Square-Pyramidal Oxovanadium (IV) Complexes Derived from Polydentate Ligand (L&lt;sup&gt;1&lt;/sup&gt;)

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New Square-Pyramidal Oxovanadium (IV) Complexes Derived from Polydentate Ligand (L<sup>1</sup>)