New Square-Pyramidal Oxovanadium (IV) Complexes Derived from Polydentate Ligand (L&amp;lt;sup&amp;gt;1&amp;lt;/sup&amp;gt;)

Hassoon, Azza A.; Al‐Radadi, Najlaa S.; Nawar, Nagwa; Mostafa, Mohsen M.

doi:10.4236/ojic.2016.61003

Cited by 11 publications

(4 citation statements)

References 48 publications

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“…The VO(II) complex displayed a band at 19,685 cm –1 assigned to 2 B 2 → 2 E 2 (ν 2 ). This spectrum, accompanied by the magnetic moment value (μ eff = 1.79 BM), is attributed to the square pyramidal configuration. − Whereas, the electronic spectrum of the Cu(II) complex displayed two transition bands at 16,207 and 14,771 cm –1 assigned to 2 B 1g → 2 E g and 2 B 1g → 2 A 1g transitions, respectively, which indicated the existence of a distorted octahedral geometry around the Cu(II) ion . Also, the magnetic moment value of [Cu( o -BMP)(H 2 O) 2 ]·2H 2 O is 2.13 BM.…”

Section: Resultsmentioning

confidence: 98%

Spectroscopic Characterization, Cyclic Voltammetry, Biological Investigations, MOE, and Gaussian Calculations of VO(II), Cu(II), and Cd(II) Heteroleptic Complexes

et al. 2023

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A novel hydrazone ligand (o-H2BMP) N-(benzo[d]thiazol-2-yl)-3-oxo-3-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)propanamide alongside its Cu(II), Cd(II), and VO(II) complexes were prepared and structurally characterized via various spectroscopic analyses (Fourier transform infrared spectroscopy, UV–visible spectroscopy, 1H/13C NMR spectroscopy, liquid chromatography coupled to mass spectrometry, and electron paramagnetic resonance spectroscopy) as well as by elemental analysis, thermal gravimetry analysis/differential thermal analysis, and magnetic moment measurements. Powder X-ray diffraction analysis was also performed for the free ligand and its metal complexes to determine the crystallographic structures and atomic spacing. It also provided information on unit cell dimensions and the average crystallite size. Furthermore, geometric optimization and computational studies were carried out by applying Gaussian (09) software based on density-functional theory coupled with the B3LYP functional and LANL2DZ/6-31+G(d,p) mixed basis set to evaluate some distinct features such as molecular electrostatic potential, E HOMO, and E LUMO. Moreover, electrochemical measurements were performed for Cu(II) in the absence/presence of the chelating agent to predict the effect of complexation interaction in the solution state study. As part of the biological examination, antioxidant and antimicrobial assays were conducted for each compound individually, in addition to cytotoxicity evaluations via MTT assays for all isolated complexes compared to the corresponding metal salts. The MOE (molecular operating environment) approach was also applied to model the interface between the isolated compounds and proteins that were expressed in breast cancer at the atomic level.

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Section: Resultsmentioning

confidence: 98%

Spectroscopic Characterization, Cyclic Voltammetry, Biological Investigations, MOE, and Gaussian Calculations of VO(II), Cu(II), and Cd(II) Heteroleptic Complexes

et al. 2023

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“…Alongside 1:1 electrolyte to (A), (B) and (D) complexes and nonelectrolyte for (C) complex. [30][31][32][33] The magnetic moment (μ eff ) for complex (A) was ended up finding to be 1.93 B.M., this value is based solely on spin data for an odd electron.…”

Section: Resultsmentioning

confidence: 99%

“…In dimethyl formamide and dimethyl sulfoxide, the metal complexes were stable and completely solubilized with molar conductivity values of range from 7.17 to 75.11 S cm 2 mol −1 . Alongside 1:1 electrolyte to (A), (B) and (D) complexes and nonelectrolyte for (C) complex 30–33 . The magnetic moment (μ eff ) for complex (A) was ended up finding to be 1.93 B.M., this value is based solely on spin data for an odd electron.…”

Section: Resultsmentioning

confidence: 99%

Newly synthesised Schiff base metal complexes, characterisation, and contribution as enhancers of colon cancer cell apoptosis by overexpression of P53 protein

El‐Hamid¹,

Sadeek

Mohammed

et al. 2023

Applied Organom Chemis

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Fluoroquinolones emerged as one of potent therapeutic agents, targeting DNA‐signalling pathways. Thus, efforts were spent to create novel quinolones for optimizing their antimicrobial and anticancer properties. Therefore, the new compound N,N′‐phenylene (bis1‐cyclopropyl‐7‐(4‐ethylpiperazin‐1‐yl)‐6‐fluoro‐1,4‐dihydroquinoline‐3‐carboxylic acid) (H2Enro‐o‐phdn) in addition to its related chelates‐contained metals were synthesised and described by spectroscopic, physical methods and thermal analyses. The reaction between H2Enro‐o‐phdn and trivalent La(III), Y(III), and Fe(III) and tetravalent Zr(IV) chloride with molar ratio 1:1 (M:H2Enro‐o‐phdn) yielded the production of chelates. The infrared results elucidate the binding mode of H2Enro‐o‐phdn by means of azomethine nitrogen and carboxylato oxygen atoms as tetradentate. The thermal analyses assured the proposed formula as well as existence of coordinated and latticed H2O molecules. Kinetic parameters for investigated metal complexes were quantified utilisation Horowitz–Metzger in addition to Coats–Redfern methods. Regarding antibacterial efficacy, Y(III) and Fe(III) complexes showed a robust inhibitory activity towards negative‐gram stained (Escherichia coli and Salmonella typhi) and positive‐Gram stained (Staphylococcus aureus and “spore‐forming” Bacillus cereus) strains. Then, we further tested the cytotoxicity of the complexes against the survival of colon‐cancer cells line (CT26). In this regard, in the descending order, Fe(III) > Zr(IV) > La(III) complexes possessed a powerful antitumour activity with IC50 values 6.38, 5.36, and 4.03 μM, respectively, compared with the anticancer drug‐reference cisplatin (16.77 μM). To understand the precise mechanism behind the tumour cell death, Western‐blotting analysis was conducted, to monitor the changes in levels of pro‐apoptotic “P53” protein after drug‐treatment. Results indicated that H2Enro‐o‐phdn with higher covalency metals, like La(III) and Zr(IV) complexes, had the highest upregulation of P53 expression in a threefold to fourfold compared cisplatin, paving the way for a novel P53‐based colon‐cancer therapies.

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“…The thiol-enol tautomerism is further supported by the 13 C NMR Spectrum of the ligand in d 6 -DMSO ( Fig.3b) where the signals at δ: 198.00, 188.30 and 137.30 ppm are assigned to C-OH, C=O and (C-SH), respectively [25]. The signals attributable to phenyl carbons appear as two multiplets at Synthesis, spectral characterization, DFT and in vitro antibacterial activity of Zn(II), Cd(II) and Hg(II)complexes derived from a new thiosemicarbazide and 28370 cm -1 presumably arising from (π→π*) and n → π*transitions {an overlap of the transitions due to those of benzene ring, carbonyl and thione groups} [26]. These bands suffer a blue shift on chelation revealing the participation of carbonyl and thione groups in coordination [27].…”

Section: Nmr Spectramentioning

confidence: 99%

Synthesis, spectral characterization, DFT and in vitro antibacterial activity of Zn(II), Cd(II) and Hg(II) complexes derived from a new thiosemicarbazide

2019

Lett Appl NanoBioSci

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A new series of mono-nuclear complexes, Cd 2+ , Zn 2+ and Hg 2+ derived from 4,4-dimethyl-2,6-dioxo-Nphenylcyclohexanecarbothioamide (HDDPT) have been prepared and characterized. The complexes adopted the molecular formulae; [Hg(DDPT)Cl(H 2 O)], [Cd (HDDPT) 2 Cl 2 ] and [Zn (HDDPT) 2 Cl 2 ], respectively. IR data showed that HDDPT ligand acts as OS bidentate either in neutral form as in Cd 2+ , Zn 2+ complexes or mononegative chelate in Hg 2+ complex. An octahedral environment was suggested for Zn 2+ and Cd 2+ complexes and a tetrahedral arrangement for Hg 2+ complex. DFT method we used to confirm the geometries of title compounds and evaluate other energetic parameters such as HOMO, LUMO, hardness, softness and electronegativity. Also, the thermal stability was examined by TGA and DrTGA and the associated thermodynamic parameters of activation were determined using Coats-Redfern and Horowitz-Metzger methods. Also, all compounds were screened for antibacterial activity using ciprofloxacin and gentamicin drugs by inhibition zone diameter method technique.

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New Square-Pyramidal Oxovanadium (IV) Complexes Derived from Polydentate Ligand (L<sup>1</sup>)

Abstract: Abstract

Cited by 11 publications

References 48 publications

Spectroscopic Characterization, Cyclic Voltammetry, Biological Investigations, MOE, and Gaussian Calculations of VO(II), Cu(II), and Cd(II) Heteroleptic Complexes

Spectroscopic Characterization, Cyclic Voltammetry, Biological Investigations, MOE, and Gaussian Calculations of VO(II), Cu(II), and Cd(II) Heteroleptic Complexes

Newly synthesised Schiff base metal complexes, characterisation, and contribution as enhancers of colon cancer cell apoptosis by overexpression of P53 protein

Synthesis, spectral characterization, DFT and in vitro antibacterial activity of Zn(II), Cd(II) and Hg(II) complexes derived from a new thiosemicarbazide

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