Synthesis, characterization, in vitro antimicrobial and anticancer evaluation of random copolyesters bearing biscoumarin units in the main chains

Kandaswamy, Narendran; Nanthini, R.

doi:10.1007/s11164-014-1806-3

Cited by 16 publications

(9 citation statements)

References 22 publications

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“…The conformer MPH-β shows C−H···C (6) and bifurcated C−H···O interactions (5) and (7). The presence of the nitrogen atom on the heterocycle increases the positive charge of hydrogen atom at para position, making pyridine more effective as a "π-hydrogen bond" donor 11 and resulting in C20−H20···C18 interaction (6). Finally, Figure 5 shows the high intensity of (5) and (7) contacts, indicating the receiver nature of the oxygen atom of C29−H29···O2 and C25−H25···O2 interactions.…”

Section: Hirshfeld Surface Analysismentioning

confidence: 99%

“…The highlighted regions (10) in Figure 7b are due to pyridine rings overlapping. The C···H contacts are characterized by the shape of "wings" namely (11) in Figure 7c and are slightly different for conformers. In MPH-α indicate hydrophobic interactions involving Cg1 and Cg3 while in MPH-β indicates the hydrophobic interaction involving Cg4 and non-classical interaction C−H···C caused by delocalized electron of pyridine (C20−H20···C18).…”

Section: Hirshfeld Surface Analysismentioning

confidence: 99%

“…[5][6][7][8][9][10] Additionally to chalcones, several studies have been reported about the heterocyclic chalcones due to their pharmacological activities, which are attributed to the structural aspects of these molecules, especially (i) the unsaturated bond between the aliphatic carbons; (ii) the ketone group; and (iii) the presence of heteroatoms. 6,11,12 The heterocyclic chalcones have a heteroaryl which contain an oxygen, sulfur or nitrogen. 12,13 The pyridine is one type of aryl group with nitrogen as heteroatom, and is assigned to numerous biological activities, such as anti-microbial, anti-tumor and anti-viral.…”

Section: Introductionmentioning

confidence: 99%

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Hirshfeld Surfaces and Nonlinear Optics on Two Conformers of a Heterocyclic Chalcone

Custódio¹,

Moreira²,

Valverde³

et al. 2017

J. Braz. Chem. Soc.

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Heterocyclic chalcones have been prominent in the scientific community due to various biological activities reported for these compounds. The structural knowledge of heterocyclic chalcones can help in the understanding of their mechanism of action. The Hirshfeld surfaces were used to study the supramolecular arrangement of two conformers present into asymmetric unit of the heterocyclic chalcone (2E)-3-(4-methylphenyl)-1-(pyridin-3-yl)-prop-2-en-1-one on crystalline state. In addition, the linear polarizability (α), the first hyperpolarizability (β||z), and the second hyperpolarizability (γ) of the conformers were calculated to get a better insight on the linear and nonlinear optical behaviors of these structures in presence of solvent medium, as well as their band-gap energies. The Hirshfeld surfaces confirmed the presence of C−H···N, C−H···O and C−H···C interactions in packaging stabilization. Finally, the 2D fingeprint plot was used to the quantification of contacts and indicated that there are both π···π and C−H···π interactions present in the compound.

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Section: Hirshfeld Surface Analysismentioning

confidence: 99%

Section: Hirshfeld Surface Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hirshfeld Surfaces and Nonlinear Optics on Two Conformers of a Heterocyclic Chalcone

Custódio¹,

Moreira²,

Valverde³

et al. 2017

J. Braz. Chem. Soc.

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“…The chemistry of these compounds (1-3) has undergone a surge of interest because of the active pharmacore unit, 2,5-dihydroxy- [1,4]-benzoquinone [12,13] and the hydrophobic nature of alkyl chain from embelin, vilangin and benzene from phenyl vilangin. In our present investigation, carbon labelled C5 and C6 of benzoquinone derivative plays a vital role in reactivity (condensation) with formaldehyde and benzaldehyde because of the presence of hydroxyl unit (-OH) at C5 and active methylene unit at C6.…”

Section: Chemistrymentioning

confidence: 99%

“…The aim of the present investigation is to assess the antibacterial activity of embelin, vilangin and phenyl vilangin against E. faecalis by disc diffusion method, and also, the MIC value was assessed for antibacterial investigation [4,5]. Brine shrimp lethality assay was performed to study about the cytotoxicity of phytochemical irrigants based on the mortality percentage of nauplii and LC 50 value.…”

Section: Introductionmentioning

confidence: 99%

Molecular docking studies, in vitro-brine shrimp lethal assay and antibacterial assessment of embelin, vilangin and phenyl vilangin against endodontic pathogen, Enterococcus faecalis

Jayalakshmi

Kandaswamy

Sukumar³

et al. 2021

Res Chem Intermed

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Complete debridement and disinfection of the root canal system are the primary requirement for successful endodontic treatment. Enterococcus faecalis is the most commonly found organism in a high percentage of root canal failures as a single organism or as a major component of the flora. Primary goal of this study is to assess the antibacterial effect of phytochemical agents namely embelin, vilangin and phenyl vilangin, respectively, against E. faecalis. And this is the first time that these materials are reported for antibacterial activity against the pathogen, E. faecalis. Our second goal is to predict the interaction between the active structure and the protein in the binding mode, and the third goal is to screen for cytotoxicity by brine shrimp lethality bioassay. All the compounds showed low to elevated level of antibacterial activity. Particularly, compound embelin, as well as its combination with NaOCl in the ratio 1:1, exhibits zone of inhibition value of 29 ± 0.89 and 32 ± 0.98 mm at a concentration of 80 µL and the MIC value of embelin was found to be 78.10 µg/mL. All the compounds exhibit low toxicity to high toxicity. The LC 50 value of tested * S. Jayalakshmi

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Synthesis of phenolphthalein/bisphenol A‐based poly(arylene ether nitrile) copolymers: Preparation and properties of films

Zhang

Liu

2022

J of Applied Polymer Sci

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Poly(arylene ether nitrile) (PEN) is a class of high‐performance engineering plastics of poly(arylene ether) with cyano groups as side groups, which can get improved thermal, mechanical, and electrical properties through simple molecular structure design. In this work, a series of PEN (BPA/PP based PEN) copolymers were synthesized with varying amounts of phenolphthalein and bisphenol A. The influence of the copolymer molecular structure variations on the thermal, mechanical, and dielectric properties of PEN copolymer films was investigated. The results demonstrated that the BPA/PP based PEN copolymer films have great mechanical properties and low dielectric constant, as well as enhanced thermal properties. The highest 5% weight loss temperature of 494.9°C was obtained by PEN‐B7P3, while the highest glass transition temperature of 238.6°C was obtained by PEN‐B3P7. Porous BPA/PP based PEN films prepared by non‐solvent induced phase separation (NIPS) exhibited satisfactory mechanical properties and the highest tensile strength of 9.4 MPa was achieved. Moreover, the introduction of the phenolphthalein structure into the PEN molecular chain can improve the heat resistance of the PEN copolymers without deteriorating the dielectric properties, which gives the copolymers great potential as candidates for applications in flexible electronics and wireless communication.

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Synthesis, characterization, in vitro antimicrobial and anticancer evaluation of random copolyesters bearing biscoumarin units in the main chains

Cited by 16 publications

References 22 publications

Hirshfeld Surfaces and Nonlinear Optics on Two Conformers of a Heterocyclic Chalcone

Hirshfeld Surfaces and Nonlinear Optics on Two Conformers of a Heterocyclic Chalcone

Molecular docking studies, in vitro-brine shrimp lethal assay and antibacterial assessment of embelin, vilangin and phenyl vilangin against endodontic pathogen, Enterococcus faecalis

Synthesis of phenolphthalein/bisphenol A‐based poly(arylene ether nitrile) copolymers: Preparation and properties of films

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